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公开(公告)号：US20180173845A1
公开(公告)日：2018-06-21
申请号：US15887864
申请日：2018-02-02
申请人： Natera, Inc.
摘要： Provided herein are improved methods for detecting aneuploidy in a sample. The methods in certain embodiments are used for the analysis of circulating DNA in serum samples, such as circulating fetal DNA or circulating tumor DNA. In certain embodiments, chromosome or chromosome segments of interest are used to set a bias model and/or a control value for a z-score determination, in illustrative examples without the use of a control chromosome.
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公开(公告)号：US20220403461A1
公开(公告)日：2022-12-22
申请号：US17845169
申请日：2022-06-21
申请人： Natera, Inc.
发明人： Huseyin Eser KIRKIZLAR , Raheleh SALARI , Styrmir SIGURJONSSON , Bernhard ZIMMERMANN , Allison RYAN , Naresh VANKAYALAPATI
IPC分类号： C12Q1/6858 , G16B20/00 , C12Q1/6869 , G16B20/10 , G16H10/40 , C12Q1/6886
摘要： The invention provides improved methods, compositions, and kits for detecting ploidy of chromosome regions, e.g. for detecting cancer or a chromosomal abnormality in a gestating fetus. The methods can utilize a set of more than 200 SNPs that are found within haploblocks and can include analyzing a series of target chromosomal regions related to cancer or a chromosomal abnormality in a gestating fetus. Finally the method may use knowledge about chromosome crossover locations or a best fit algorithm for the analysis. The compositions may comprise more than 200 primers located within haplotype blocks known to show CNV.
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公开(公告)号：US20180173846A1
公开(公告)日：2018-06-21
申请号：US15887914
申请日：2018-02-02
申请人： Natera, Inc.
摘要： Provided herein are improved methods for detecting aneuploidy in a sample. The methods in certain embodiments are used for the analysis of circulating DNA in serum samples, such as circulating fetal DNA or circulating tumor DNA. In certain embodiments, chromosome or chromosome segments of interest are used to set a bias model and/or a control value for a z-score determination, in illustrative examples without the use of a control chromosome.
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公开(公告)号：US20240301482A1
公开(公告)日：2024-09-12
申请号：US18441502
申请日：2024-02-14
申请人： Natera, Inc.
发明人： Huseyin Eser KIRKIZLAR , Raheleh SALARI , Stymir SIGURJONSSON , Bernhard ZIMMERMANN , Allison RYAN , Naresh VANKAYALAPATI
IPC分类号： C12Q1/6858 , C12Q1/6853 , C12Q1/6869 , C12Q1/6886 , G16B20/00 , G16B20/10 , G16H10/40
CPC分类号： C12Q1/6858 , C12Q1/6853 , C12Q1/6869 , C12Q1/6886 , G16B20/00 , G16B20/10 , G16H10/40 , C12Q2539/10 , C12Q2600/106 , C12Q2600/156 , Y02A90/10
摘要： The invention provides improved methods, compositions, and kits for detecting ploidy of chromosome regions, e.g. for detecting cancer or a chromosomal abnormality in a gestating fetus. The methods can utilize a set of more than 200 SNPs that are found within haploblocks and can include analyzing a series of target chromosomal regions related to cancer or a chromosomal abnormality in a gestating fetus. Finally the method may use knowledge about chromosome crossover locations or a best fit algorithm for the analysis. The compositions may comprise more than 200 primers located within haplotype blocks known to show CNV.
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公开(公告)号：US20210398609A1
公开(公告)日：2021-12-23
申请号：US17465424
申请日：2021-09-02
申请人： Natera, Inc.
摘要： Provided herein are improved methods for detecting aneuploidy in a sample. The methods in certain embodiments are used for the analysis of circulating DNA in serum samples, such as circulating fetal DNA or circulating tumor DNA. In certain embodiments, chromosome or chromosome segments of interest are used to set a bias model and/or a control value for a z-score determination, in illustrative examples without the use of a control chromosome.
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公开(公告)号：US20180148777A1
公开(公告)日：2018-05-31
申请号：US15573800
申请日：2016-05-10
申请人： Natera, Inc.
发明人： Huseyin Eser KIRKIZLAR , Raheleh SALARI , Styrmir SIGURJONSSON , Bernhard ZIMMERMANN , Allison RYAN , Naresh VANKAYALAPATI
IPC分类号： C12Q1/6858 , C12Q1/6869 , C12Q1/6886 , G06F19/18 , G16H10/40
CPC分类号： C12Q1/6858 , C12Q1/6869 , C12Q1/6886 , C12Q2539/10 , C12Q2600/106 , C12Q2600/156 , G16B20/00 , G16H10/40 , Y02A90/26
摘要： The invention provides improved methods, compositions, and kits for detecting ploidy of chromosome regions, e.g. for detecting cancer or a chromosomal abnormality in a gestating fetus. The methods can utilize a set of more than 200 SNPs that are found within haploblocks and can include analyzing a series of target chromosomal regions related to cancer or a chromosomal abnormality in a gestating fetus. Finally the method may use knowledge about chromosome crossover locations or a best fit algorithm for the analysis. The compositions may comprise more than 200 primers located within haplotype blocks known to show CNV.
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