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公开(公告)号：US20250011870A1
公开(公告)日：2025-01-09
申请号：US18733471
申请日：2024-06-04
Applicant: Natera, Inc.
Inventor： Matthew RABINOWITZ , Matthew Micah HILL , Bernhard A. ZIMMERMANN , Johan BANER , George GEMELOS , Milena BANJEVIC , Allison RYAN , Styrmir SIGURJONSSON , Zachary DEMKO
IPC: C12Q1/6883 , C12Q1/6809 , C12Q1/6811 , C12Q1/6844 , C12Q1/6848 , C12Q1/6851 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874
Abstract: The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US20240327919A1
公开(公告)日：2024-10-03
申请号：US18747138
申请日：2024-06-18
Applicant: Natera, Inc.
Inventor： MATTHEW RABINOWITZ , Matthew Micah HILL , Bernhard ZIMMERMANN , Johan BANER , George GEMELOS , Milena Eser BANJEVIC , Allison RYAN , Styrmir SIGURJONSSON , Zachary DEMKO
IPC: C12Q1/6883 , C12Q1/6809 , C12Q1/6811 , C12Q1/6844 , C12Q1/6848 , C12Q1/6851 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874
CPC classification number: C12Q1/6883 , C12Q1/6809 , C12Q1/6811 , C12Q1/6844 , C12Q1/6848 , C12Q1/6851 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874 , C12Q2600/156
Abstract: The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US20240318252A1
公开(公告)日：2024-09-26
申请号：US18733659
申请日：2024-06-04
Applicant: Natera, Inc.
Inventor： Matthew RABINOWITZ , Matthew Micah HILL , Bernhard A. ZIMMERMANN , Johan BANER , George GEMELOS , Milena BANJEVIC , Allison RYAN , Styrmir SIGURJONSSON , Zachary DEMKO
IPC: C12Q1/6883 , C12Q1/6809 , C12Q1/6811 , C12Q1/6844 , C12Q1/6848 , C12Q1/6851 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874
CPC classification number: C12Q1/6883 , C12Q1/6809 , C12Q1/6811 , C12Q1/6844 , C12Q1/6848 , C12Q1/6851 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874 , C12Q2600/156
Abstract: The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US20230343411A1
公开(公告)日：2023-10-26
申请号：US18220183
申请日：2023-07-10
Applicant: Natera, Inc.
Inventor： Matthew RABINOWITZ , George GEMELOS , Milena BANJEVIC , Allison RYAN , Zachary DEMKO , Matthew HILL , Bernhard ZIMMERMANN , Johan BANER
IPC: G16B20/00 , C12Q1/6827 , C12Q1/6862 , C12Q1/686 , G16B20/10 , G16B20/20 , G16B20/40 , C12Q1/6883 , C12Q1/6869 , C12Q1/6806 , C12Q1/6874
CPC classification number: G16B20/00 , C12Q1/6827 , C12Q1/6862 , C12Q1/686 , G16B20/10 , G16B20/20 , G16B20/40 , C12Q1/6883 , C12Q1/6869 , C12Q1/6806 , C12Q1/6874 , G16B40/00
Abstract: The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.
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公开(公告)号：US20230203573A1
公开(公告)日：2023-06-29
申请号：US17925693
申请日：2021-05-27
Applicant: Natera, Inc.
Inventor： Ryan SWENERTON , Bernhard ZIMMERMANN , Ebad AHMED , Nathan LIANG , Allison RYAN , Fei LU , Paul VAN HUMMELEN
IPC: C12Q1/6851 , C12Q1/686 , C12Q1/6876
CPC classification number: C12Q1/6851 , C12Q1/686 , C12Q1/6876 , C12Q2600/158
Abstract: The present disclosure provides methods for quantifying the amount of total cell-free DNA in a biological sample, comprising: isolating cell-free DNA from the biological sample, wherein a first Tracer DNA composition is added before or after isolation of the cell-free DNA; performing targeted amplification at 100 or more different target loci in a single reaction volume using 100 or more different primer pairs; sequencing the amplification products by high-throughput sequencing to generate sequencing reads; and quantifying the amount of total cell-free DNA using sequencing reads derived from the first Tracer DNA composition.
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Patent Agency Ranking
公开(公告)号：US20210222240A1
公开(公告)日：2021-07-22
申请号：US17214485
申请日：2021-03-26
Applicant: Natera, Inc.
Inventor： Solomon MOSHKEVICH , Bernhard ZIMMERMANN , Tudor Pompiliu CONSTANTIN , Huseyin Eser KIRKIZLAR , Allison RYAN , Styrmir SIGURJONSSON , Felipe ACOSTA ARCHILA , Ryan SWENERTON
IPC: C12Q1/6869 , C12Q1/6876 , C12Q1/6851
Abstract: The present disclosure provides methods for determining the status of an allograft within a transplant recipient from genotypic data measured from a mixed sample of DNA comprising DNA from both the transplant recipient and from the donor. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.
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公开(公告)号：US20180057885A1
公开(公告)日：2018-03-01
申请号：US15805871
申请日：2017-11-07
Applicant: Natera, Inc.
Inventor： Matthew RABINOWITZ , George GEMELOS , Milena BANJEVIC , Allison RYAN , Zachary DEMKO , Matthew HILL , Bernhard ZIMMERMANN , Johan BANER
CPC classification number: C12Q1/6883 , C12Q1/6827 , C12Q1/6869 , C12Q2537/161 , C12Q2537/165 , C12Q2600/112 , C12Q2600/156 , C12Q2600/16 , C12Q2600/172 , G06F19/34 , G16B5/00 , G16B20/00 , G16B30/00 , G16H50/30
Abstract: The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a sample of DNA from the mother of the fetus and from the fetus, and from genotypic data from the mother and optionally also from the father. The ploidy state is determined by using a joint distribution model to create a set of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. In an embodiment, the mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias.
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公开(公告)号：US20240271214A1
公开(公告)日：2024-08-15
申请号：US18620822
申请日：2024-03-28
Applicant: Natera, Inc.
Inventor： MATTHEW RABINOWITZ , Matthew Micah HILL , Bernhard ZIMMERMANN , Johan BANER , George GEMELOS , Milena BANJEVIC , Allison RYAN , Styrmir SIGURJONSSON , Zachary DEMKO
IPC: C12Q1/6883 , C12Q1/6809 , C12Q1/6811 , C12Q1/6844 , C12Q1/6848 , C12Q1/6851 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874
CPC classification number: C12Q1/6883 , C12Q1/6809 , C12Q1/6811 , C12Q1/6844 , C12Q1/6848 , C12Q1/6851 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874 , C12Q2600/156
Abstract: The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US20240038328A1
公开(公告)日：2024-02-01
申请号：US18371383
申请日：2023-09-21
Applicant: Natera, Inc.
Inventor： Matthew RABINOWITZ , George GEMELOS , Milena BANJEVIC , Allison RYAN , Zachary DEMKO , Matthew HILL , Bernhard ZIMMERMANN , Johan BANER
IPC: G16B20/00 , C12Q1/6827 , C12Q1/6862 , C12Q1/686 , G16B20/10 , G16B20/20 , G16B20/40 , C12Q1/6883 , C12Q1/6869 , C12Q1/6806 , C12Q1/6874
CPC classification number: G16B20/00 , C12Q1/6827 , C12Q1/6862 , C12Q1/686 , G16B20/10 , G16B20/20 , G16B20/40 , C12Q1/6883 , C12Q1/6869 , C12Q1/6806 , C12Q1/6874 , G16B40/00
Abstract: The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.
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公开(公告)号：US20230287497A1
公开(公告)日：2023-09-14
申请号：US17252068
申请日：2019-07-03
Applicant: Natera, Inc.
Inventor： Solomon MOSHKEVICH , Bernhard ZIMMERMANN , Tudor Pompiliu CONSTANTIN , Huseyin Eser KIRKIZLAR , Allison RYAN , Styrmir SIGURJONSSON , Felipe ACOSTA ARCHILA , Ryan SWENERTON
IPC: C12Q1/6883
CPC classification number: C12Q1/6883 , C12Q2600/156
Abstract: The present disclosure provides methods for determining the status of an allograft within a transplant recipient from genotypic data measured from a mixed sample of DNA comprising DNA from both the transplant recipient and from the donor. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.
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