- 专利标题： Manipulated Immunoregulatory Element And Immunity Altered Thereby
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申请号： US16324955申请日： 2017-08-14
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公开(公告)号： US20190185860A1公开(公告)日： 2019-06-20
- 发明人: Seok Joong KIM , Yoon-Young KIM , Ho-Sung YU , In-Young JUNG , Jung Min LEE
- 申请人： TOOLGEN INCORPORATED
- 优先权： KR10-2016-0103308 20160812
- 国际申请： PCT/KR2017/008835 WO 20170814
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; C12N15/85 ; C12N5/0784 ; C12N5/0783 ; C12N9/22 ; C12N15/52
摘要：
The present invention relates to an artificially manipulated immune system having an improved immune effect. More particularly, the present invention relates to an immune system having functions artificially altered which comprises artificially manipulated immunoregulatory elements and cells containing the same. Contemplated according to a particular embodiment is an immune system comprising artificially manipulated immunoregulatory genes such as PD-1, CTLA-4, A20, DGKα, DGKζ, FAS, EGR2, PPP2R2D, PSGL-1, KDM6A, and TET2, and/or expression products thereof.
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