-
公开(公告)号:US20210147798A1
公开(公告)日:2021-05-20
申请号:US16611383
申请日:2018-05-08
申请人: TOOLGEN INCORPORATED
发明人: Seok Joong KIM , Yoon-Young KIM , Ho-Sung YU , In-Young JUNG , Jung Min LEE
IPC分类号: C12N5/078 , C12N9/22 , C12N15/113 , C12N15/115 , C12N15/10 , C07K14/705 , C12N15/87
摘要: The presents invention relates to a composition for manipulating an immune cell which is used for artificially manipulating an immune cell. More particularly, the present invention relates to a composition for manipulating an immune cell which is used for artificially manipulating an immune cell and a manipulated immune cell comprising an artificially modified immunity regulating gene and an artificial receptor which is produced using the composition, and use thereof.
-
2.
公开(公告)号:US20240102035A1
公开(公告)日:2024-03-28
申请号:US18522962
申请日:2023-11-29
申请人: TOOLGEN INCORPORATED
发明人: Seok Joong KIM , Ok Jae KOO , Min Hee JUNG , Ye Seul KIM
CPC分类号: C12N15/8247 , C12N9/22 , C12N15/11 , C12N2310/20 , C12N2800/80
摘要: The present invention relates to an artificially manipulated unsaturated fatty acid biosynthesis-associated factor and use thereof to increase the content of a specific unsaturated fatty acid of a plant body. More particularly, the present invention relates to a system capable of artificially controlling unsaturated fatty acid biosynthesis and a plant body produced thereby, which include an artificially manipulated unsaturated fatty acid biosynthesis-associated factor to control unsaturated fatty acid biosynthesis and a composition capable of artificially manipulating the factor. In a specific aspect, the present invention relates to artificially manipulated unsaturated fatty acid biosynthesis-associated factors such as FAD2, FAD3, FAD6, FAD7 and FAD8 and/or an unsaturated fatty acid biosynthesis controlling system by an expression product thereof.
-
3.
公开(公告)号:US20220228160A1
公开(公告)日:2022-07-21
申请号:US17706921
申请日:2022-03-29
申请人: TOOLGEN INCORPORATED
发明人: Seok Joong KIM , Ok Jae KOO , Min Hee JUNG , Ye Seul KIM
摘要: The present invention relates to an artificially manipulated unsaturated fatty acid biosynthesis-associated factor and use thereof to increase the content of a specific unsaturated fatty acid of a plant body. More particularly, the present invention relates to a system capable of artificially controlling unsaturated fatty acid biosynthesis and a plant body produced thereby, which include an artificially manipulated unsaturated fatty acid biosynthesis-associated factor to control unsaturated fatty acid biosynthesis and a composition capable of artificially manipulating the factor. In a specific aspect, the present invention relates to artificially manipulated unsaturated fatty acid biosynthesis-associated factors such as FAD2, FAD3, FADE, FAD7 and FAD8 and/or an unsaturated fatty acid biosynthesis controlling system by an expression product thereof.
-
4.
公开(公告)号:US20200208166A1
公开(公告)日:2020-07-02
申请号:US16471443
申请日:2017-09-26
申请人: TOOLGEN INCORPORATED
发明人: Seok Joong KIM , Ok Jae KOO , Min Hee JUNG , Ye Seul KIM
摘要: The present invention relates to an artificially manipulated unsaturated fatty acid biosynthesis-associated factor and use thereof to increase the content of a specific unsaturated fatty acid of a plant body. More particularly, the present invention relates to a system capable of artificially controlling unsaturated fatty acid biosynthesis and a plant body produced thereby, which include an artificially manipulated unsaturated fatty acid biosynthesis-associated factor to control unsaturated fatty acid biosynthesis and a composition capable of artificially manipulating the factor. In a specific aspect, the present invention relates to artificially manipulated unsaturated fatty acid biosynthesis-associated factors such as FAD2, FAD3, FADE, FAD7 and FAD8 and/or an unsaturated fatty acid biosynthesis controlling system by an expression product thereof.
-
公开(公告)号:US20190276503A1
公开(公告)日:2019-09-12
申请号:US16349672
申请日:2017-09-28
申请人: TOOLGEN INCORPORATED
发明人: Seok Joong KIM , Dong Woo SONG , Young Bin HONG , Byung Ok CHOI , Jae Young LEE , Jung Min LEE
IPC分类号: C07K14/315 , C12N15/86 , A61K35/30
摘要: The present invention relates to an artificially manipulated SC function-controlling factor for SC function control and/or the treatment or alleviation of a disease due to an SC function disorder, and to a use thereof. More specifically, the present invention relates to a system capable of performing artificial SC function control and/or treating or alleviating a disease due to an SC function disorder, the system comprising: an artificially manipulated SC function-controlling factor for SC function control and/or the treatment or alleviation of a disease due to an SC function disorder; and/or a composition for treating or alleviating a disease due to an SC function disorder. In a specific aspect, the present invention relates to an SC function-controlling system by an SC function-controlling factor, such as artificially manipulated PMP22, and/or an expression product thereof.
-
公开(公告)号:US20190185860A1
公开(公告)日:2019-06-20
申请号:US16324955
申请日:2017-08-14
申请人: TOOLGEN INCORPORATED
发明人: Seok Joong KIM , Yoon-Young KIM , Ho-Sung YU , In-Young JUNG , Jung Min LEE
IPC分类号: C12N15/113 , C12N15/85 , C12N5/0784 , C12N5/0783 , C12N9/22 , C12N15/52
CPC分类号: C12N15/1132 , A61K35/14 , C12N5/0637 , C12N5/0638 , C12N5/064 , C12N5/0646 , C12N9/22 , C12N15/52 , C12N15/63 , C12N15/85 , Y02A50/47
摘要: The present invention relates to an artificially manipulated immune system having an improved immune effect. More particularly, the present invention relates to an immune system having functions artificially altered which comprises artificially manipulated immunoregulatory elements and cells containing the same. Contemplated according to a particular embodiment is an immune system comprising artificially manipulated immunoregulatory genes such as PD-1, CTLA-4, A20, DGKα, DGKζ, FAS, EGR2, PPP2R2D, PSGL-1, KDM6A, and TET2, and/or expression products thereof.
-
-
-
-
-