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公开(公告)号：US20210147798A1
公开(公告)日：2021-05-20
申请号：US16611383
申请日：2018-05-08
Applicant: TOOLGEN INCORPORATED
Inventor： Seok Joong KIM , Yoon-Young KIM , Ho-Sung YU , In-Young JUNG , Jung Min LEE
IPC: C12N5/078 , C12N9/22 , C12N15/113 , C12N15/115 , C12N15/10 , C07K14/705 , C12N15/87
Abstract: The presents invention relates to a composition for manipulating an immune cell which is used for artificially manipulating an immune cell. More particularly, the present invention relates to a composition for manipulating an immune cell which is used for artificially manipulating an immune cell and a manipulated immune cell comprising an artificially modified immunity regulating gene and an artificial receptor which is produced using the composition, and use thereof.
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公开(公告)号：US20200277630A1
公开(公告)日：2020-09-03
申请号：US16650993
申请日：2018-09-28
Applicant: TOOLGEN INCORPORATED , SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , SEOUL NATIONAL UNIVERSITY HOSPITAL
Inventor： Dong Woo SONG , Jung Min LEE , Un Gi KIM , Jeong Hun KIM , Dong Hyun JO
IPC: C12N15/86 , C12N15/113 , C12N9/22 , A61P27/02
Abstract: The present invention relates to a composition for gene manipulation for treating or improving a retinal dysfunction disease or a method using the same. More particularly, the present invention relates to a composition for gene manipulation including a guide nucleic acid capable of targeting a retinal function-forming gene and a method of treating or improving a disease caused by retinal dysfunction by artificially manipulating and/or correcting a retinal function-forming gene using the same.
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Patent Agency Ranking
公开(公告)号：US20210317448A1
公开(公告)日：2021-10-14
申请号：US17262342
申请日：2019-07-25
Applicant: TOOLGEN INCORPORATED
Inventor： Dong Woo SONG , Jung Min LEE , Kyu Jun LEE , Un Gi KIM
Abstract: The present invention relates to a composition for gene manipulation for artificially manipulating a blood coagulation inhibitory gene present in the genome of a cell to regulate a blood coagulation system. More particularly, the present invention relates to a composition for gene manipulation, which includes a guide nucleic acid capable of targeting a blood coagulation inhibitory gene, and an editor protein. Also, the present invention relates to a method of treating or improving coagulopathy using the composition for gene manipulation for artificially manipulating a blood coagulation inhibitory gene.
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公开(公告)号：US20230293645A1
公开(公告)日：2023-09-21
申请号：US17604498
申请日：2020-04-20
Applicant: TOOLGEN INCORPORATED , HANDONG GLOBAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION , KONKUK UNIVERSITY GLOCAL INDUSTRY-ACADEMIC COLLABORATION FOUNDATION
Inventor： Jae Young LEE , Kyu Jun LEE , Jung Min LEE , Kyun Hwan KIM , Ju Hee WON
CPC classification number: A61K38/465 , C12N9/22 , C12N15/11 , C12N15/85 , C12N15/88 , C12N5/067 , A61K31/7105 , A61P31/20 , C12N2310/20 , C12N2800/80 , C12N2800/107
Abstract: The present application relates to a composition and method for inhibiting Hepatitis B virus (HBV) proliferation.
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公开(公告)号：US20190276503A1
公开(公告)日：2019-09-12
申请号：US16349672
申请日：2017-09-28
Applicant: TOOLGEN INCORPORATED
Inventor： Seok Joong KIM , Dong Woo SONG , Young Bin HONG , Byung Ok CHOI , Jae Young LEE , Jung Min LEE
IPC: C07K14/315 , C12N15/86 , A61K35/30
Abstract: The present invention relates to an artificially manipulated SC function-controlling factor for SC function control and/or the treatment or alleviation of a disease due to an SC function disorder, and to a use thereof. More specifically, the present invention relates to a system capable of performing artificial SC function control and/or treating or alleviating a disease due to an SC function disorder, the system comprising: an artificially manipulated SC function-controlling factor for SC function control and/or the treatment or alleviation of a disease due to an SC function disorder; and/or a composition for treating or alleviating a disease due to an SC function disorder. In a specific aspect, the present invention relates to an SC function-controlling system by an SC function-controlling factor, such as artificially manipulated PMP22, and/or an expression product thereof.
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公开(公告)号：US20190185860A1
公开(公告)日：2019-06-20
申请号：US16324955
申请日：2017-08-14
Applicant: TOOLGEN INCORPORATED
Inventor： Seok Joong KIM , Yoon-Young KIM , Ho-Sung YU , In-Young JUNG , Jung Min LEE
IPC: C12N15/113 , C12N15/85 , C12N5/0784 , C12N5/0783 , C12N9/22 , C12N15/52
CPC classification number: C12N15/1132 , A61K35/14 , C12N5/0637 , C12N5/0638 , C12N5/064 , C12N5/0646 , C12N9/22 , C12N15/52 , C12N15/63 , C12N15/85 , Y02A50/47
Abstract: The present invention relates to an artificially manipulated immune system having an improved immune effect. More particularly, the present invention relates to an immune system having functions artificially altered which comprises artificially manipulated immunoregulatory elements and cells containing the same. Contemplated according to a particular embodiment is an immune system comprising artificially manipulated immunoregulatory genes such as PD-1, CTLA-4, A20, DGKα, DGKζ, FAS, EGR2, PPP2R2D, PSGL-1, KDM6A, and TET2, and/or expression products thereof.
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公开(公告)号：US20230295652A1
公开(公告)日：2023-09-21
申请号：US18147156
申请日：2022-12-28
Applicant: TOOLGEN INCORPORATED
Inventor： Seokjoong KIM , Dong Woo SONG , Jae Young LEE , Jung Min LEE , Gyu-bon CHO , Hee Sook BAE
IPC: C12N15/85 , C12N15/113 , C12N9/22
CPC classification number: C12N15/85 , C12N9/22 , C12N15/113 , C12N2310/20
Abstract: The present invention relates to an expression control composition for controlling the expression of a duplicate gene or a method using the same. In addition, the present invention relates to a method of treating or improving a disease caused by gene duplication using the expression control composition for controlling the expression of a duplicate gene.
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