Invention Application
- Patent Title: AGENT FOR RESTORING VISUAL FUNCTION OR AGENT FOR PREVENTING DETERIORATION IN VISUAL FUNCTION
-
Application No.: US16329631Application Date: 2017-09-01
-
Publication No.: US20190194294A1Publication Date: 2019-06-27
- Inventor: Toshihide Kurihara , Yusaku Katada , Hiromitsu Kunimi , Kazuo Tsubota , Hideki Kandori
- Applicant: KEIO UNIVERSITY , NAGOYA INSTITUTE OF TECHNOLOGY
- Priority: JP2016-172149 20160902
- International Application: PCT/JP2017/031579 WO 20170901
- Main IPC: C07K14/72
- IPC: C07K14/72 ; C07K14/195 ; A61P27/02 ; C12N15/86

Abstract:
The purpose of the present invention is to provide an agent for restoring a visual function or an agent for preventing the deterioration in a visual function, which has an excellent visual function restoring ability. The agent for regenerating a visual function or the agent for preventing the deterioration in a visual function according to the present invention contains, as an active ingredient, a chimeric protein having both an amino acid sequence for a microorganism-origin ion-transporting receptor rhodopsin and an amino acid sequence for an animal-origin G-protein-coupled receptor rhodopsin. The chimeric protein is preferably one in which an amino acid sequence for a cytoplasm-side second loop and/or a cytoplasm-side third loop in the amino acid sequence for the microorganism-origin ion-transporting receptor rhodopsin is substituted by an amino acid sequence for a cytoplasm-side second loop and/or a cytoplasm-side third loop in the G-protein-coupled receptor rhodopsin.
Public/Granted literature
- US11932679B2 Agent for restoring visual function or agent for preventing deterioration in visual function Public/Granted day:2024-03-19
Information query