- 专利标题： MODULATION OF INTESTINAL EPITHELIAL CELL DIFFERENTIATION, MAINTENANCE AND/OR FUNCTION THROUGH T CELL ACTION
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申请号： US16348911申请日： 2017-11-07
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公开(公告)号： US20190263912A1公开(公告)日： 2019-08-29
- 发明人: Adam Haber , Moshe Biton , Rebecca H. Herbst , Karthik Shekhar , Christopher Smillie , Orit Rozenblatt-Rosen , Ramnik Xavier , Aviv Regev , Jose Ordovas-Montanes , Alexander K. Shalek , Noga Rogel
- 申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , The General Hospital Corporation
- 国际申请： PCT/US2017/060469 WO 20171107
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; C07K14/47 ; C07K14/52 ; A61K35/17 ; C07K14/71 ; C12N5/0783 ; G01N33/50 ; C12N5/071 ; A61P1/04 ; A61P1/14 ; G01N33/569 ; A61P33/00 ; A61P31/04
摘要：
An atlas of intestinal epithelial cells, intestinal epithelial stem cells and intestinal immune cells identifies new cell populations, markers, networks, and responses to stimuli. Intestinal T cells drive intestinal epithelial cell differentiation and activity. Accordingly, disclosed are methods of modulating intestinal epithelial cell differentiation, maintenance and/or function, related methods for the treatment of disease, including IBD. Also disclosed are methods and kits for identifying cell types, their differentiation, homeostasis and activation.
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