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公开(公告)号：US20230000912A1
公开(公告)日：2023-01-05
申请号：US16072674
申请日：2017-01-25
申请人： THE BROAD INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE GENERAL HOSPITAL CORPORATION
发明人： Bradley Bernstein , Itay Tirosh , Mario Suva , Aviv Regev , Orit Rozenblatt-Rosen , Andrew Venteicher
IPC分类号： A61K35/17 , C12Q1/6886 , A61P35/00 , G01N33/574 , C07K16/30
摘要： This invention relates generally to compositions and methods for identifying genes and gene networks that respond to, modulate, control or otherwise influence tumors and tissues, including cells and cell types of the tumors and tissues, and malignant, microenvironmental, or immunologic states of the tumor cells and tissues. The invention also relates to methods of diagnosing, prognosing and/or staging of tumors, tissues and cells, and provides compositions and methods of modulating expression of genes and gene networks of tumors, tissues and cells, as well as methods of identifying, designing and selecting appropriate treatment regimens.
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公开(公告)号：US20210115407A1
公开(公告)日：2021-04-22
申请号：US16604596
申请日：2018-04-12
申请人： The Broad Institute, Inc. , The General Hospital Corporation , Massachusetts Institute of Technology
发明人： Jayaraj Rajagopal , Aviv Regev , Moshe Biton , Adam Haber , Daniel Montoro , Orit Rozenblatt-Rosen
摘要： Provided herein are methods and compositions for identifying ionocytes from respiratory epithelial cells, and uses of such cells for treatment of inflammatory lung disease. Also provided herein are methods and compositions for modulating respiratory tract epithelial cell proliferation, differentiation, maintenance, and/or function.
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3.发明申请公开(公告)号：US20220411783A1
公开(公告)日：2022-12-29
申请号：US17284542
申请日：2019-10-11
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , The General Hospital Corporation
发明人： Aviv Regev , Cristin McCabe , Eugene Drokhlyansky , Alexandre Melnikov , Orit Rozenblatt-Rosen , Christopher S. Smillie , Ramnik J. Xavier , Orr Ashenberg , Gökcen Eraslan , Hattie Chung
摘要： The subject matter disclosed herein is generally directed to isolating single cells and nuclei from tissue samples for use in the analysis of single cells from archived biological samples. The subject matter disclosed herein is directed to isolating single cells and nuclei from formalin-fixed paraffin-embedded (FFPE) tissues. The subject matter disclosed herein is also directed to isolating single nuclei that preserve ribosomes or ribosomes and rough ER from frozen tissues. The subject matter disclosed herein is also directed to therapeutic targets, diagnostic targets and methods of screening for modulating agents.
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4.发明申请公开(公告)号：US20180100201A1
公开(公告)日：2018-04-12
申请号：US15844601
申请日：2017-12-17
申请人： The Broad Institute Inc. , Massachusetts Institute of Technology , Dana-Farber Cancer Institute, Inc. , The General Hospital Corporation
发明人： Levi A. Garraway , Benjamin Izar , Sanjay Prakadan , Aviv Regev , Orit Rozenblatt-Rosen , Alexander K. Shalek , Mario Suva , Itay Tirosh , Andrew Venteicher , Marc H. Wadsworth II , Bradley Bernstein , Anuraag Parikh , Sidharth Puram
IPC分类号： C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158
摘要： This invention relates generally to compositions and methods for identifying genes and gene networks that respond to, modulate, control or otherwise influence tumors and tissues, including cells and cell types of the tumors and tissues, and malignant, microenvironmental, or immunologic states of the tumor cells and tissues. The invention also relates to methods of diagnosing, prognosing and/or staging of tumors, tissues and cells, and provides compositions and methods of modulating expression of genes and gene networks of tumors, tissues and cells, as well as methods of identifying, designing and selecting appropriate treatment regimens. The invention also relates to the modulation of complement activity to shift cellular immunity and obtain an effective therapeutic response.
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公开(公告)号：US20210047694A1
公开(公告)日：2021-02-18
申请号：US16995425
申请日：2020-08-17
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , The General Hospital Corporation
发明人： Aviv Regev , Nir Hacohen , Vijay K. Kuchroo , Ana Carrizosa Anderson , Orit Rozenblatt-Rosen , Jonathan Chen , Karin Pelka , Matan Hofree
IPC分类号： C12Q1/6886
摘要： The present invention is generally directed to a colorectal (CRC) cell atlas that provides methods of predicting outcomes of cancer patients and therapeutic targets for treating patients in need thereof. The atlas may be used to predict a response to immunotherapy, in particular checkpoint blockade therapy and adoptive cell transfer. Disclosed herein are previously unidentified gene programs in tumors that can be used to predict response and provide for therapeutic targets that can be used to shift a tumor to a responsive phenotype.
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6.发明申请公开(公告)号：US20190263912A1
公开(公告)日：2019-08-29
申请号：US16348911
申请日：2017-11-07
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , The General Hospital Corporation
发明人： Adam Haber , Moshe Biton , Rebecca H. Herbst , Karthik Shekhar , Christopher Smillie , Orit Rozenblatt-Rosen , Ramnik Xavier , Aviv Regev , Jose Ordovas-Montanes , Alexander K. Shalek , Noga Rogel
IPC分类号： C07K16/28 , C07K14/47 , C07K14/52 , A61K35/17 , C07K14/71 , C12N5/0783 , G01N33/50 , C12N5/071 , A61P1/04 , A61P1/14 , G01N33/569 , A61P33/00 , A61P31/04
摘要： An atlas of intestinal epithelial cells, intestinal epithelial stem cells and intestinal immune cells identifies new cell populations, markers, networks, and responses to stimuli. Intestinal T cells drive intestinal epithelial cell differentiation and activity. Accordingly, disclosed are methods of modulating intestinal epithelial cell differentiation, maintenance and/or function, related methods for the treatment of disease, including IBD. Also disclosed are methods and kits for identifying cell types, their differentiation, homeostasis and activation.
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公开(公告)号：US11963966B2
公开(公告)日：2024-04-23
申请号：US16499393
申请日：2018-03-30
申请人： Dana-Farber Cancer Institute, Inc. , The Broad Institute, Inc. , Massachusetts Institute of Technology
发明人： Levi Garraway , Benjamin Izar , Aviv Regev , Orit Rozenblatt-Rosen , Asaf Rotem , Elizabeth Stover , Itay Tirosh
IPC分类号： A61K31/575 , A61K9/00 , A61K33/243 , A61K35/17 , A61K39/395
CPC分类号： A61K31/575 , A61K9/0019 , A61K33/243 , A61K35/17 , A61K39/39533
摘要： Described herein are compositions and methods of using single-cell RNA-sequencing to identify treatment resistance in patients with ovarian cancer. Also, described herein are compositions and methods for treatment targeting resistance in patients with ovarian cancer.
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公开(公告)号：US11981922B2
公开(公告)日：2024-05-14
申请号：US17063604
申请日：2020-10-05
申请人： Dana-Farber Cancer Institute, Inc. , The Broad Institute, Inc. , Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc.
发明人： Meromit Singer , Aviv Regev , Orit Rozenblatt-Rosen , Davide Mangani , Ana Carrizosa Anderson , Vijay K. Kuchroo , Linglin Huang
IPC分类号： A61K35/17 , A61K39/395 , C07K16/18 , C07K16/22 , C07K16/28 , C07K16/38 , C07K16/40 , C12N5/0783 , C12Q1/6886 , A61K39/00
CPC分类号： C12N5/0638 , A61K35/17 , A61K39/39541 , A61K39/3955 , C07K16/18 , C07K16/22 , C07K16/2803 , C07K16/2818 , C07K16/2827 , C07K16/2863 , C07K16/2896 , C07K16/38 , C07K16/40 , C12Q1/6886 , A61K2039/507 , C07K2317/76 , C12Q2600/106
摘要： The present invention is generally directed to identify interacting cells in the tumor microenvironment and using the identified interactions to enhance anti-tumor immunity in cancer. Identified interactions can be modulated using therapeutic agents. Immune cells resistant to suppression can be used for adoptive cell transfer. The present invention is also generally directed to cell types and genes that are correlated to time of tumor growth and tumor size.
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公开(公告)号：US20220249701A1
公开(公告)日：2022-08-11
申请号：US17610942
申请日：2020-05-14
IPC分类号： A61K48/00 , C12N9/22 , C12N15/11 , C12N15/62 , C12N15/86 , C12N15/90 , C12N9/78 , A61K35/76 , A61K38/46 , A61K31/7088 , A61P21/00
摘要： The present invention provides for methods and compositions for specifically targeting a nuclei type in a multinucleated cell or population of multinucleated cells, wherein the composition comprises one or more nucleotide sequences operably linked to one or more regulatory sequences specifically active in the nuclei.
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公开(公告)号：US20210171938A1
公开(公告)日：2021-06-10
申请号：US16770380
申请日：2018-12-07
IPC分类号： C12N15/10
摘要： The present invention provides methods and tools for analyzing genetic interactions. The subject matter disclosed herein is generally directed to single cell genomics and proteomics. In one embodiment provided is a method of cell and nuclei hashing using sample barcodes. In another embodiment are method of performing genomewide CRISPR perturbation screens.
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