Embodiments of the present disclosure provide quantum circuit assemblies that implement adaptive programming of quantum dot qubit devices. An example quantum circuit assembly includes a quantum circuit component including a quantum dot qubit device, and a control logic coupled to the quantum circuit component. The control logic is configured to adaptively program the quantum dot qubit device by iterating a sequence of applying one or more signals to the quantum dot qubit device, determining a state of at least one qubit of the quantum dot qubit device, and using the determined state to modify the signals to be applied to the quantum dot qubit device in the next iteration. In this manner, the signals may be fine-tuned to achieve a higher probability of the qubit(s) in the quantum dot qubit device being set to the desired state.