Invention Application
- Patent Title: DECREASING ORNITHINE METABOLISM TO DECREASE THE HIGH MANNOSE GLYCOFORM CONTENT OF RECOMBINANT PROTEINS
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Application No.: US16676340Application Date: 2019-11-06
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Publication No.: US20200071738A1Publication Date: 2020-03-05
- Inventor: Sohye KANG , Chung HUANG, JR. , Hedieh BARKHORDARIAN , Pavel BONDARENKO , Zhongqi ZHANG
- Applicant: Amgen Inc.
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Main IPC: C12P21/00
- IPC: C12P21/00 ; C07K16/00 ; C07K14/52 ; C12N5/071 ; C12N1/38
Abstract:
The present invention relates to a method for manipulating the high mannose glycoform content of recombinant glycoproteins by regulating ornithine metabolism during cell culture.
Public/Granted literature
- US11254963B2 Increasing ornithine accumulation to increase high mannose glycoform content of recombinant proteins Public/Granted day:2022-02-22
Information query
