Invention Application
- Patent Title: METHOD FOR PURIFYING ACTIVE POLYPEPTIDES OR IMMUNOCONJUGATES
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Application No.: US16786634Application Date: 2020-02-10
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Publication No.: US20200231680A1Publication Date: 2020-07-23
- Inventor: Thomas LINKE , William K. WANG , Ambarish SHAH , Hasige SATHISH , Alan HUNTER , Christopher THOMPSON
- Applicant: MedImmune Limited
- Main IPC: C07K16/28
- IPC: C07K16/28 ; B01D15/16 ; B01D15/36 ; B01J41/14 ; B01J41/20 ; A61K47/68 ; C07K1/18 ; C07K17/02 ; A61K39/395 ; A61K47/02
Abstract:
The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography. The present invention also provides compositions, formulations, and unit dosage forms comprising the purified polypeptide or immunoconjugate.
Public/Granted literature
- US11136396B2 Method for purifying active polypeptides or immunoconjugates Public/Granted day:2021-10-05
Information query
