- 专利标题： PREFUSION RSV F PROTEINS AND THEIR USE
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申请号： US17478533申请日： 2021-09-17
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公开(公告)号： US20220002351A1公开(公告)日： 2022-01-06
- 发明人: Peter D. Kwong , Barney S. Graham , Jason S. McLellan , Jeffrey Boyington , Lei Chen , Man Chen , Gwo-Yu Chuang , Ivelin Stefanov Georgiev , Jason Gorman , Michael Gordon Joyce , Masaru Kanekiyo , Gilad Ofek , Marie Pancera , Mallika Sastry , Cinque Soto , Sanjay Srivatsan , Guillaume Stewart-Jones , Yongping Yang , Baoshan Zhang , Tongqing Zhou
- 申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
- 申请人地址： US MD Bethesda
- 专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
- 当前专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
- 当前专利权人地址： US MD Bethesda
- 主分类号： C07K14/005
- IPC分类号： C07K14/005 ; A61K39/12 ; A61K39/155 ; C12N7/00 ; G01N33/564
摘要：
Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.
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