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公开(公告)号：US20240024458A1
公开(公告)日：2024-01-25
申请号：US18462340
申请日：2023-09-06
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , Institute For Research in Biomedicine
发明人： Peter Kwong , Michael Gordon Joyce , Baoshan Zhang , Yongping Yang , Peter Collins , Ursula Buchholz , Davide Corti , Antonio Lanzavecchia , Guillaume Stewart-Jones
IPC分类号： A61K39/155 , A61K39/39 , C07K14/005 , A61K48/00 , C07K14/135
CPC分类号： A61K39/155 , A61K39/39 , C07K14/005 , A61K48/00 , C07K14/135 , C07K2319/73 , C12N2760/18322 , C12N2760/18334 , C07K2319/70 , C12N2760/18522 , C12N2760/18534
摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
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公开(公告)号：US20230227512A1
公开(公告)日：2023-07-20
申请号：US17937719
申请日：2022-10-03
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Peter Kwong , Marie Pancera , Tongqing Zhou , Ivelin Georgiev , Michael Gordon Joyce , Priyamvada Acharya , Jason Gorman , Yongping Yang , Guillaume Stewart-Jones , Rita Chen , Gwo-Yu Chuang , John Mascola , Baoshan Zhang , Cheng Cheng , Mallika Sastry , Aliaksandr Druz
IPC分类号： C07K14/435 , A61K39/12 , C07K14/005 , A61K39/21 , C07K16/10 , G01N33/569
CPC分类号： C07K14/435 , A61K39/12 , C07K14/005 , A61K39/21 , C07K16/1063 , G01N33/56988 , C12N2740/16122 , C12N2740/16134 , A61K2039/55555
摘要： HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.
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公开(公告)号：US20220064222A1
公开(公告)日：2022-03-03
申请号：US17524380
申请日：2021-11-11
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Peter Kwong , Barney Graham , John Mascola , Li Ou , Aliaksandr Druz , Man Chen , Wing-Pui Kong , Ivelin Stefanov Georgiev , Emily Rundlet , Michael Gordon Joyce , Yaroslav Tsybovsky , Paul Thomas , Marie Pancera , Mallika Sastry , Cinque Soto , Joseph Van Galen , Guillaume Stewart-Jones , Yongping Yang , Baoshan Zhang , Ulrich Baxa
IPC分类号： C07K14/005 , A61K39/12 , A61P37/04 , A61P31/14
摘要： Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.
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公开(公告)号：US20210299242A1
公开(公告)日：2021-09-30
申请号：US17261828
申请日：2019-08-05
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , Trustees of Dartmouth College
IPC分类号： A61K39/155 , C07K14/005 , A61P31/14
摘要： Embodiments of immunogens comprising a recombinant Nipah virus (NiV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also provided are embodiments of immunogens comprising chimeric proteins comprising the recombinant NiV F ectodomain trimer and one or more G ectodomains, a multimer of NiV G ectodomains, and protein nanoparticles comprising the recombinant NiV F ectodomain trimer or an NiV G ectodomain. Also disclosed are nucleic acids encoding the immunogens and methods of their production. Methods for inducing an immune response in a subject by administering a disclosed immunogen to the subject are also provided. In some embodiments, the immune response treats or inhibits NiV infection in a subject.
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公开(公告)号：US20240101609A1
公开(公告)日：2024-03-28
申请号：US18537448
申请日：2023-12-12
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , Institute for Research in Biomedicine
发明人： Baoshan Zhang , Guillaume Stewart-Jones , Tongqing Zhou , John Mascola , Kai Xu , Yongping Yang , Paul Thomas , Gwo-Yu Chuang , Li Ou , Peter Kwong , Yaroslav Tsybovsky , Wing-Pui Kong , Aliaksandr Druz , Davide Corti , Antonio Lanzavecchia
IPC分类号： C07K14/005 , A61K39/155 , A61P31/14 , C12N7/00
CPC分类号： C07K14/005 , A61K39/155 , A61P31/14 , C12N7/00 , C07K2319/50 , C12N2760/18634 , C12N2760/18734
摘要： Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.
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公开(公告)号：US20200009243A1
公开(公告)日：2020-01-09
申请号：US16578748
申请日：2019-09-23
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , Institute for Research in Biomedicine
发明人： Peter Kwong , Michael Gordon Joyce , Baoshan Zhang , Yongping Yang , Peter Collins , Ursula Buchholz , Davide Corti , Antonio Lanzavecchia , Guillaume Stewart-Jones
IPC分类号： A61K39/155 , A61K39/39 , A61K48/00 , C07K14/005 , C07K14/135
摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
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公开(公告)号：US20230053555A1
公开(公告)日：2023-02-23
申请号：US17784605
申请日：2020-12-11
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
IPC分类号： A61K39/165 , A61P31/14 , C07K14/12
摘要： Embodiments of immunogens comprising a recombinant Mumps (MuV) F ectodomain trimer stabilized in a prefusion conformation or a recombinant Measles (MeV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also provided are embodiments of immunogens comprising chimeric proteins comprising the recombinant MuV or MeV F ectodomain trimer and one or more MuV HN or MeV H ectodomains. Also disclosed are nucleic acids encoding the immunogens and methods of their production. Methods for inducing an immune response in a subject by administering a disclosed immunogen to the subject are also provided. In some embodiments, the immune response treats or inhibits MuV and/or MeV infection in a subject.
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公开(公告)号：US20210283240A1
公开(公告)日：2021-09-16
申请号：US17334505
申请日：2021-05-28
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , Institute for Research in Biomedicine
发明人： Peter Kwong , Michael Gordon Joyce , Baoshan Zhang , Yongping Yang , Peter Collins , Ursula Buchholz , Davide Corti , Antonio Lanzavecchia , Guillaume Stewart-Jones
IPC分类号： A61K39/155 , A61K39/39 , C07K14/005 , A61K48/00 , C07K14/135
摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
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公开(公告)号：US20220002351A1
公开(公告)日：2022-01-06
申请号：US17478533
申请日：2021-09-17
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Peter D. Kwong , Barney S. Graham , Jason S. McLellan , Jeffrey Boyington , Lei Chen , Man Chen , Gwo-Yu Chuang , Ivelin Stefanov Georgiev , Jason Gorman , Michael Gordon Joyce , Masaru Kanekiyo , Gilad Ofek , Marie Pancera , Mallika Sastry , Cinque Soto , Sanjay Srivatsan , Guillaume Stewart-Jones , Yongping Yang , Baoshan Zhang , Tongqing Zhou
IPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , C12N7/00 , G01N33/564
摘要： Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.
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