公开(公告)号：US20240024458A1

公开(公告)日：2024-01-25

申请号：US18462340

申请日：2023-09-06

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic ,  Institute For Research in Biomedicine

发明人： Peter Kwong ,  Michael Gordon Joyce ,  Baoshan Zhang ,  Yongping Yang ,  Peter Collins ,  Ursula Buchholz ,  Davide Corti ,  Antonio Lanzavecchia ,  Guillaume Stewart-Jones

IPC分类号： A61K39/155 ,  A61K39/39 ,  C07K14/005 ,  A61K48/00 ,  C07K14/135

CPC分类号： A61K39/155 ,  A61K39/39 ,  C07K14/005 ,  A61K48/00 ,  C07K14/135 ,  C07K2319/73 ,  C12N2760/18322 ,  C12N2760/18334 ,  C07K2319/70 ,  C12N2760/18522 ,  C12N2760/18534

摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.

公开(公告)号：US20230227512A1

公开(公告)日：2023-07-20

申请号：US17937719

申请日：2022-10-03

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Peter Kwong ,  Marie Pancera ,  Tongqing Zhou ,  Ivelin Georgiev ,  Michael Gordon Joyce ,  Priyamvada Acharya ,  Jason Gorman ,  Yongping Yang ,  Guillaume Stewart-Jones ,  Rita Chen ,  Gwo-Yu Chuang ,  John Mascola ,  Baoshan Zhang ,  Cheng Cheng ,  Mallika Sastry ,  Aliaksandr Druz

IPC分类号： C07K14/435 ,  A61K39/12 ,  C07K14/005 ,  A61K39/21 ,  C07K16/10 ,  G01N33/569

CPC分类号： C07K14/435 ,  A61K39/12 ,  C07K14/005 ,  A61K39/21 ,  C07K16/1063 ,  G01N33/56988 ,  C12N2740/16122 ,  C12N2740/16134 ,  A61K2039/55555

摘要： HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.

公开(公告)号：US20220064222A1

公开(公告)日：2022-03-03

申请号：US17524380

申请日：2021-11-11

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Peter Kwong ,  Barney Graham ,  John Mascola ,  Li Ou ,  Aliaksandr Druz ,  Man Chen ,  Wing-Pui Kong ,  Ivelin Stefanov Georgiev ,  Emily Rundlet ,  Michael Gordon Joyce ,  Yaroslav Tsybovsky ,  Paul Thomas ,  Marie Pancera ,  Mallika Sastry ,  Cinque Soto ,  Joseph Van Galen ,  Guillaume Stewart-Jones ,  Yongping Yang ,  Baoshan Zhang ,  Ulrich Baxa

IPC分类号： C07K14/005 ,  A61K39/12 ,  A61P37/04 ,  A61P31/14

摘要： Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.

公开(公告)号：US20210198324A1

公开(公告)日：2021-07-01

申请号：US17202231

申请日：2021-03-15

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Peter Kwong ,  Ivelin Georgiev ,  Michael Gordon Joyce ,  Masaru Kanekiyo ,  Aliaksandr Druz ,  Ulrich Baxa ,  Joseph Van Galen ,  Cheng Cheng ,  John Mascola ,  Yaroslav Tsybovsky ,  Yongping Yang ,  Barney Graham ,  Syed Mohammad Moin ,  Jeffrey Boyington

IPC分类号： C07K14/11 ,  A61K39/21 ,  C07K14/08 ,  C07K14/16 ,  C07K14/165 ,  C07K14/435 ,  C12N7/00

摘要： Disclosed are recombinant insect ferritin nanoparticles that can be used to display two different trimeric antigens at an equal ratio. Also disclosed are nucleic acids encoding the recombinant insect ferritin nanoparticles and methods of producing the recombinant insect ferritin nanoparticles. Methods for eliciting an immune response in a subject are also provided.

公开(公告)号：US20200009243A1

公开(公告)日：2020-01-09

申请号：US16578748

申请日：2019-09-23

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic ,  Institute for Research in Biomedicine

发明人： Peter Kwong ,  Michael Gordon Joyce ,  Baoshan Zhang ,  Yongping Yang ,  Peter Collins ,  Ursula Buchholz ,  Davide Corti ,  Antonio Lanzavecchia ,  Guillaume Stewart-Jones

IPC分类号： A61K39/155 ,  A61K39/39 ,  A61K48/00 ,  C07K14/005 ,  C07K14/135

摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.

公开(公告)号：US20200230229A1

公开(公告)日：2020-07-23

申请号：US16338964

申请日：2017-10-03

申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC

发明人： Peter Kwong ,  Rui Kong ,  Tongqing Zhou ,  John Mascola ,  Kai Xu ,  Michael Gordon Joyce ,  Cheng Cheng ,  Gwo-Yu Chuang ,  Kevin Liu ,  Baoshan Zhang ,  Li Ou ,  Wing-Pui Kong ,  Yongping Yang

IPC分类号： A61K39/21 ,  C12N7/00 ,  A61K47/64 ,  A61P31/18 ,  C07K14/005

摘要： Embodiments of immunogens based on the HIV-1 Env fusion peptide and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to generate an immune response to HIV-1 Env in a subject, for example, to treat or prevent an HIV-1 infection in the subject.

公开(公告)号：US20210283240A1

公开(公告)日：2021-09-16

申请号：US17334505

申请日：2021-05-28

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic ,  Institute for Research in Biomedicine

发明人： Peter Kwong ,  Michael Gordon Joyce ,  Baoshan Zhang ,  Yongping Yang ,  Peter Collins ,  Ursula Buchholz ,  Davide Corti ,  Antonio Lanzavecchia ,  Guillaume Stewart-Jones

IPC分类号： A61K39/155 ,  A61K39/39 ,  C07K14/005 ,  A61K48/00 ,  C07K14/135

摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.

公开(公告)号：US20220002351A1

公开(公告)日：2022-01-06

申请号：US17478533

申请日：2021-09-17

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Peter D. Kwong ,  Barney S. Graham ,  Jason S. McLellan ,  Jeffrey Boyington ,  Lei Chen ,  Man Chen ,  Gwo-Yu Chuang ,  Ivelin Stefanov Georgiev ,  Jason Gorman ,  Michael Gordon Joyce ,  Masaru Kanekiyo ,  Gilad Ofek ,  Marie Pancera ,  Mallika Sastry ,  Cinque Soto ,  Sanjay Srivatsan ,  Guillaume Stewart-Jones ,  Yongping Yang ,  Baoshan Zhang ,  Tongqing Zhou

IPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/155 ,  C12N7/00 ,  G01N33/564

摘要： Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.

公开(公告)号：US20210275664A1

公开(公告)日：2021-09-09

申请号：US17194834

申请日：2021-03-08

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic ,  The Scripps Research Institute ,  Trustees of Dartmouth College

发明人： Barney Graham ,  Jason McLellan ,  Andrew Ward ,  Robert Kirchdoerfer ,  Christopher Cottrell ,  Michael Gordon Joyce ,  Masaru Kanekiyo ,  Nianshuang Wang ,  Jesper Pallesen ,  Hadi Yassine ,  Hannah Turner ,  Kizzmekia Corbett

IPC分类号： A61K39/215 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00

摘要： Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.

公开(公告)号：US20200061185A1

公开(公告)日：2020-02-27

申请号：US16344774

申请日：2017-10-25

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic ,  The Scripps Research Institute ,  Trustees of Dartmouth College

发明人： Barney Graham ,  Jason McLellan ,  Andrew Ward ,  Robert Kirchdoerfer ,  Christopher Cottrell ,  Michael Gordon Joyce ,  Masaru Kanekiyo ,  Nianshuang Wang ,  Jesper Pallesen ,  Hadi Yassine ,  Hannah Turner ,  Kizzmekia Corbett

IPC分类号： A61K39/215 ,  C07K14/005 ,  A61P31/14 ,  C12N7/00

摘要： Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.