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公开(公告)号：US20240294665A1
公开(公告)日：2024-09-05
申请号：US18663557
申请日：2024-05-14
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Qiong J. Wang , Zhiya Yu , James C. Yang
IPC分类号： C07K16/30 , A61K35/17 , A61P35/00 , C07K14/705 , C07K14/715 , C07K14/725 , C07K16/28
CPC分类号： C07K16/30 , A61P35/00 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K14/7153 , C07K16/2875 , A61K35/17 , C07K2317/60 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/33
摘要： The invention provides a chimeric antigen receptor (CAR) having antigenic specificity for CD70, the CAR comprising: an antigen binding-transmembrane domain comprising a CD27 amino acid sequence lacking all or a portion of the CD27 intracellular T cell signaling domain; a 4-1BB intracellular T cell signaling domain; a CD3ζ intracellular T cell signaling domain; and optionally, a CD28 intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.
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公开(公告)号：US20240209059A1
公开(公告)日：2024-06-27
申请号：US18423020
申请日：2024-01-25
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Eric Tran , Yong-Chen Lu , Anna Pasetto , Paul F. Robbins , Steven A. Rosenberg , Zhili Zheng
IPC分类号： C07K14/725 , A61P35/00 , C07K14/82 , C12N15/85 , G01N33/574
CPC分类号： C07K14/7051 , A61P35/00 , C07K14/82 , C12N15/85 , G01N33/57407 , A61K38/00 , G01N2333/7051
摘要： Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) presented in the context of an HLA-Cw*0802 molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
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公开(公告)号：US20240050554A1
公开(公告)日：2024-02-15
申请号：US18491193
申请日：2023-10-20
申请人： The United States of America, as represented by the Secretary, department of Health and Human Servic
发明人： Jeffrey C. Boyington , Barney S. Graham , John R. Mascola , Hadi M. Yassine , Kizzmekia S. Corbett , Syed M. Moin , Lingshu Wang , Masaru Kanekiyo
IPC分类号： A61K39/145 , C07K14/005 , C07K14/195 , A61K39/12 , A61P31/16
CPC分类号： A61K39/145 , C07K14/005 , C07K14/195 , A61K39/12 , A61P31/16 , A61K2039/55555
摘要： Vaccines that elicit broadly protective anti-influenza antibodies. The vaccines comprise nanoparticles that display HA trimers from Group 2 influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to stabilized stem regions of Group 2 influenza virus HA proteins. The fusion proteins self-assemble to form the HA-displaying nanoparticles. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.
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公开(公告)号：US20240041931A1
公开(公告)日：2024-02-08
申请号：US18266455
申请日：2021-12-10
申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC
IPC分类号： A61K35/24 , A61K39/395 , A61K35/741 , A61P35/00
CPC分类号： A61K35/24 , A61K39/3955 , A61K35/741 , A61P35/00 , A61K2035/115
摘要： Disclosed herein are methods for treating cancer by administering an anti-PD-1 antibody and a fecal sample obtained from a donor that is responsive to an anti-PD-1 therapy. Specifically, the cancer comprising a melanoma, and a metastatic melanoma; and wherein the fecal sample comprises a higher level of bacteria of phylum Actinobacteria and/or phylum Firmicutes in comparison to a control.
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公开(公告)号：US20240024458A1
公开(公告)日：2024-01-25
申请号：US18462340
申请日：2023-09-06
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic , Institute For Research in Biomedicine
发明人： Peter Kwong , Michael Gordon Joyce , Baoshan Zhang , Yongping Yang , Peter Collins , Ursula Buchholz , Davide Corti , Antonio Lanzavecchia , Guillaume Stewart-Jones
IPC分类号： A61K39/155 , A61K39/39 , C07K14/005 , A61K48/00 , C07K14/135
CPC分类号： A61K39/155 , A61K39/39 , C07K14/005 , A61K48/00 , C07K14/135 , C07K2319/73 , C12N2760/18322 , C12N2760/18334 , C07K2319/70 , C12N2760/18522 , C12N2760/18534
摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
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6.发明公开公开(公告)号：US20240018210A1
公开(公告)日：2024-01-18
申请号：US18036112
申请日：2021-11-12
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC
IPC分类号： C07K14/725 , A61K39/00
CPC分类号： C07K14/7051 , A61K39/4611 , A61K39/4632 , A61K39/4631 , A61K2239/22
摘要： Disclosed is a cell expressing a modified CD3 subunit chain or a cell expressing a modified non-CD3 subunit chain comprising one or more of: (a) at least one Immuno-receptor Tyrosine-based Activation Motif (ITAM) deletion; or (b) at least one exogenous intracellular hematopoietic cell signaling domain; and (c) at least one modified ITAM comprising an amino acid sequence of Formula I. Related populations of cells, pharmaceutical compositions, methods of making the cells, methods of treating or preventing a condition in a subject, and methods of enhancing an antigen-specific immune response in a subject are also disclosed.
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公开(公告)号：US20230331655A1
公开(公告)日：2023-10-19
申请号：US18043163
申请日：2021-08-27
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC , THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF VETERANS AFFAIRS
发明人： Todd GOULD , Jaclyn HIGHLAND , Panos ZANOS , Craig THOMAS , Patrick MORRIS
IPC分类号： C07C225/20 , A61P25/24
CPC分类号： C07C225/20 , A61P25/24 , C07C2601/14
摘要： Compounds and methods of using the same for treating diseases and conditions including a depressive disorder, an anxiety disorder, drug addiction, schizophrenia, Alzheimer's dementia, amyotrophic lateral sclerosis, complex regional pain syndrome (CRPS), chronic pain, neuropathic pain, anhedonia, and fatigue are provided.
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公开(公告)号：US20230277688A1
公开(公告)日：2023-09-07
申请号：US18056356
申请日：2022-11-17
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
CPC分类号： A61K48/0066 , C07K14/435 , A61P43/00 , A61K47/26 , C12N15/67 , C12N15/85 , C12N2750/14143
摘要： The present invention provides a synthetic MMACHC polynucleotide comprising a polynucleotide encoding MMACHC that is codon-optimized for expression in a human. Also provided is a polypeptide encoded by a synthetic MMACHC polynucleotide, an expression vector comprising a MMACHC gene sequence under the control of a chicken beta actin (CBA) promoter, and an expression vector comprising a synthetic MMACHC polynucleotide. Methods of treating cobalamin C deficiency and for detecting or tracking exogenous MMACHC are also provided.
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公开(公告)号：US20230227512A1
公开(公告)日：2023-07-20
申请号：US17937719
申请日：2022-10-03
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Peter Kwong , Marie Pancera , Tongqing Zhou , Ivelin Georgiev , Michael Gordon Joyce , Priyamvada Acharya , Jason Gorman , Yongping Yang , Guillaume Stewart-Jones , Rita Chen , Gwo-Yu Chuang , John Mascola , Baoshan Zhang , Cheng Cheng , Mallika Sastry , Aliaksandr Druz
IPC分类号： C07K14/435 , A61K39/12 , C07K14/005 , A61K39/21 , C07K16/10 , G01N33/569
CPC分类号： C07K14/435 , A61K39/12 , C07K14/005 , A61K39/21 , C07K16/1063 , G01N33/56988 , C12N2740/16122 , C12N2740/16134 , A61K2039/55555
摘要： HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.
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公开(公告)号：US20230212509A1
公开(公告)日：2023-07-06
申请号：US18000008
申请日：2021-05-28
申请人： FUJIFILM Cellular Dynamics, Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Andrew DIAS , Erich BERNDT , Lucas CHASE , Juan AMARAL , Arvydas MAMINISHKIS , Kapil BHARTI
IPC分类号： C12N5/0793 , C12N5/079 , A61L27/36 , C12N5/00 , A61L27/18 , A61L27/56 , A61L27/58 , A61L27/20 , A61L27/22 , A61L27/54
CPC分类号： C12N5/062 , A61L27/18 , A61L27/20 , A61L27/54 , A61L27/56 , A61L27/58 , A61L27/227 , A61L27/3641 , C12N5/0056 , C12N5/0621 , A61L2430/16 , C12N2533/40 , C12N2533/50 , C12N2533/90
摘要： Provided herein are methods of producing a distinct bilayer culture of retinal epithelial cells (RPE) with photoreceptor cells and/or photoreceptor precursor cells (PR/PRP). Further provided herein is a therapy comprising transplantation of the RPE and PR/PRP bilayer as well as methods for testing candidate drugs using the bilayer.
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