![PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF](/docs/US/2022-03-10/US20220073530A1/abs.jpg.600x600.jpg)
- 专利标题： PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF
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申请号： US17527717申请日： 2021-11-16
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公开(公告)号： US20220073530A1公开(公告)日： 2022-03-10
- 发明人: Ayman ALLIAN , Jayanthy JAYANTH , Mohamed-Eslam F. MOHAMED , Mathew MULHERN , Fredrik Lars NORDSTROM , Ahmed A. OTHMAN , Michael J. ROZEMA , Lakshmi BHAGAVATULA , Patrick J. MARROUM , Peter T. MAYER , Ahmad Y. SHEIKH , Thomas B. BORCHARDT , Ben KLÜNDER
- 申请人： AbbVie Inc.
- 申请人地址： US IL North Chicago
- 专利权人： AbbVie Inc.
- 当前专利权人： AbbVie Inc.
- 当前专利权人地址： US IL North Chicago
- 主分类号： C07D487/14
- IPC分类号： C07D487/14 ; A61K9/00 ; A61K31/4985 ; A61K47/12 ; A61K47/38
![PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF](/abs-image/US/2022/03/10/US20220073530A1/abs.jpg.150x150.jpg)
摘要：
The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis), kits, methods of synthesis, and products-by-process.
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