Technologies for secure device configuration and management include a computing device having an I/O device. A trusted agent of the computing device is trusted by a virtual machine monitor of the computing device. The trusted agent securely commands the I/O device to enter a trusted I/O mode, securely commands the I/O device to set a global lock on configuration registers, receives configuration data from the I/O device, and provides the configuration data to a trusted execution environment. In the trusted I/O mode, the I/O device rejects a configuration command if a configuration register associated with the configuration command is locked and the configuration command is not received from the trusted agent. The trusted agent may provide attestation information to the trusted execution environment. The trusted execution environment may verify the configuration data and the attestation information. Other embodiments are described and claimed.