Invention Application
- Patent Title: Use of Toll-Like Receptor 4 Agonists to Treat Inflammation and Tissue Injury
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Application No.: US17508855Application Date: 2021-10-22
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Publication No.: US20220127579A1Publication Date: 2022-04-28
- Inventor: Peiman HEMATTI , John KINK , Christian CAPITINI , Matthew FORSBERG , Nicholas HESS , Zachary ROSENKRANS , Reinier HERNANDEZ
- Applicant: Wisconsin Alumni Research Foundation
- Applicant Address: US WI Madison
- Assignee: Wisconsin Alumni Research Foundation
- Current Assignee: Wisconsin Alumni Research Foundation
- Current Assignee Address: US WI Madison
- Main IPC: C12N5/0775
- IPC: C12N5/0775 ; C12N5/0786 ; A61K35/35 ; A61K35/15
Abstract:
The disclosure relates to populations of educated macrophages and monocytes generated ex vivo or in vivo, and methods of making and using the same using lipid A aminoalkylglucosaminide phosphate molecules, such as CRX molecules or extracellular vesicles (EVs) from mesenchymal stromal cells (MSC) stimulated with CRX molecules. Also described are EVs and methods for making and using the same from MSCs exposed to CRX.
Information query
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