公开(公告)号：US20240287462A1

公开(公告)日：2024-08-29

申请号：US18624848

申请日：2024-04-02

Applicant: Wisconsin Alumni Research Foundation

Inventor： Peiman HEMATTI ,  John KINK ,  Christian CAPITINI ,  Matthew FORSBERG ,  Nicholas HESS ,  Zachary ROSENKRANS ,  Reinier Hernandez

IPC: C12N5/0775 ,  A61K35/15 ,  A61K35/35 ,  C12N5/0786

CPC classification number: C12N5/0668 ,  A61K35/15 ,  A61K35/35 ,  C12N5/0645 ,  C12N2500/84 ,  C12N2502/1323 ,  C12N2502/1358

Abstract: The disclosure relates to populations of educated macrophages and monocytes generated ex vivo or in vivo, and methods of making and using the same using lipid A aminoalkyl glucosaminide phosphate molecules, such as CRX molecules or extracellular vesicles (EVs) from mesenchymal stromal cells (MSC) stimulated with CRX molecules. Also described are EVs and methods for making and using the same from MSCs exposed to CRX.

公开(公告)号：US20220127579A1

公开(公告)日：2022-04-28

申请号：US17508855

申请日：2021-10-22

Applicant: Wisconsin Alumni Research Foundation

Inventor： Peiman HEMATTI ,  John KINK ,  Christian CAPITINI ,  Matthew FORSBERG ,  Nicholas HESS ,  Zachary ROSENKRANS ,  Reinier HERNANDEZ

IPC: C12N5/0775 ,  C12N5/0786 ,  A61K35/35 ,  A61K35/15

Abstract: The disclosure relates to populations of educated macrophages and monocytes generated ex vivo or in vivo, and methods of making and using the same using lipid A aminoalkylglucosaminide phosphate molecules, such as CRX molecules or extracellular vesicles (EVs) from mesenchymal stromal cells (MSC) stimulated with CRX molecules. Also described are EVs and methods for making and using the same from MSCs exposed to CRX.