公开(公告)号：US20230173112A1

公开(公告)日：2023-06-08

申请号：US18161395

申请日：2023-01-30

Applicant: Wisconsin Alumni Research Foundation

Inventor： Reinier HERNANDEZ ,  Anatoly PINCHUK

IPC: A61K51/04 ,  A61P35/00 ,  A61P13/08

CPC classification number: A61K51/0497 ,  A61P13/08 ,  A61P35/00

Abstract: Theranostic agents incorporating a chelating moiety that can chelate a radioactive metal isotope and a PSMA-targeting moiety are disclosed herein. The theranostic agents, which can be used to treat and/or detect cancers associated with increased PSMA expression, have the formula:





and include complexes, anions or salts thereof. Ri includes a chelating moiety; a is 0 or 1; n is an integer from 12 to 21; and R2 includes a prostate specific membrane antigen (PSMA)-targeting moiety. Optionally, the chelating moiety is chelated to a metal atom, where the metal atom is a positron or single photon emitting metal isotope, or an alpha, beta, or Auger emitting metal isotope.

公开(公告)号：US20230302164A1

公开(公告)日：2023-09-28

申请号：US18303708

申请日：2023-04-20

Applicant: Wisconsin Alumni Research Foundation

Inventor： Reinier HERNANDEZ ,  Anatoly PINCHUK

IPC: A61K51/04 ,  A61P35/00 ,  A61P13/08

CPC classification number: A61K51/0497 ,  A61P13/08 ,  A61P35/00

Abstract: Theranostic agents incorporating a chelating moiety that can chelate a radioactive metal isotope and a PSMA-targeting moiety are disclosed herein. The theranostic agents, which can be used to treat and/or detect cancers associated with increased PSMA expression, have the formula:





and include complexes, anions or salts thereof. R1 includes a chelating moiety; a is 0 or 1; n is an integer from 12 to 21; and R2 includes a prostate specific membrane antigen (PSMA)-targeting moiety. Optionally, the chelating moiety is chelated to a metal atom, where the metal atom is a positron or single photon emitting metal isotope, or an alpha, beta, or Auger emitting metal isotope.

公开(公告)号：US20220127579A1

公开(公告)日：2022-04-28

申请号：US17508855

申请日：2021-10-22

Applicant: Wisconsin Alumni Research Foundation

Inventor： Peiman HEMATTI ,  John KINK ,  Christian CAPITINI ,  Matthew FORSBERG ,  Nicholas HESS ,  Zachary ROSENKRANS ,  Reinier HERNANDEZ

IPC: C12N5/0775 ,  C12N5/0786 ,  A61K35/35 ,  A61K35/15

Abstract: The disclosure relates to populations of educated macrophages and monocytes generated ex vivo or in vivo, and methods of making and using the same using lipid A aminoalkylglucosaminide phosphate molecules, such as CRX molecules or extracellular vesicles (EVs) from mesenchymal stromal cells (MSC) stimulated with CRX molecules. Also described are EVs and methods for making and using the same from MSCs exposed to CRX.