Invention Application
- Patent Title: CRYSTALLINE FORMS OF 4-(7-HYDROXY-2-ISOPROPYL-4-OXO-4H-QUINAZOLIN-3-YL)-BENZONITRILE AND FORMULATIONS THEREOF
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Application No.: US17430819Application Date: 2020-02-13
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Publication No.: US20220162170A1Publication Date: 2022-05-26
- Inventor: Joseph Paul BULLOCK , Chinmay MAHESHWARI , Quintus MEDLEY , Muneto MOGI , Michela MONTECCHI-PALMER , Gregory MORANDI , Michael MUTZ , Kalliopi STASI , Christopher Stephen TOWLER
- Applicant: Novartis AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- International Application: PCT/IB2020/051212 WO 20200213
- Main IPC: C07D239/91
- IPC: C07D239/91
Abstract:
The present disclosure provides polymorphs and formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I). The present disclosure further provides methods for treating ocular surface pain by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I). The present invention also provides methods for treating dry eye disease and ocular hyperemia by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile.
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