公开(公告)号：US20220162170A1

公开(公告)日：2022-05-26

申请号：US17430819

申请日：2020-02-13

Applicant: Novartis AG

Inventor： Joseph Paul BULLOCK ,  Chinmay MAHESHWARI ,  Quintus MEDLEY ,  Muneto MOGI ,  Michela MONTECCHI-PALMER ,  Gregory MORANDI ,  Michael MUTZ ,  Kalliopi STASI ,  Christopher Stephen TOWLER

IPC: C07D239/91

Abstract: The present disclosure provides polymorphs and formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I). The present disclosure further provides methods for treating ocular surface pain by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I). The present invention also provides methods for treating dry eye disease and ocular hyperemia by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile.