Patent search ap:("Novartis AG") AND inv:"Chinmay MAHESHWARI" Page 1

1.

发明申请
Formulations of 4-(7-Hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile 有权

公开(公告)号：US20230139170A1

公开(公告)日：2023-05-04

申请号：US17930578

申请日：2022-09-08

Applicant: Novartis AG

Inventor： Joseph Paul BULLOCK , Chinmay MAHESHWARI , Quintus MEDLEY , Muneto MOGI , Michela MONTECCHI-PALMER , Kalliopi STASI

IPC: A61K31/517 , A61K47/02 , A61K47/10 , A61K47/26 , A61K47/38

Abstract: The present invention provides formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I) and methods for treating ocular surface pain by administering such formulations. The present invention also provides methods for treating dry eye disease and ocular hyperemia by administering formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile.

2.

发明申请
CRYSTALLINE FORMS OF 4-(7-HYDROXY-2-ISOPROPYL-4-OXO-4H-QUINAZOLIN-3-YL)-BENZONITRILE AND FORMULATIONS THEREOF 有权

公开(公告)号：US20220162170A1

公开(公告)日：2022-05-26

申请号：US17430819

申请日：2020-02-13

Applicant: Novartis AG

Inventor： Joseph Paul BULLOCK , Chinmay MAHESHWARI , Quintus MEDLEY , Muneto MOGI , Michela MONTECCHI-PALMER , Gregory MORANDI , Michael MUTZ , Kalliopi STASI , Christopher Stephen TOWLER

IPC: C07D239/91

Abstract: The present disclosure provides polymorphs and formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I). The present disclosure further provides methods for treating ocular surface pain by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I). The present invention also provides methods for treating dry eye disease and ocular hyperemia by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile.

3.

发明申请
Formulations of 4-(7-Hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile 审中-公开

公开(公告)号：US20200261457A1

公开(公告)日：2020-08-20

申请号：US16789976

申请日：2020-02-13

Applicant: NOVARTIS AG

Inventor： Joseph Paul BULLOCK , Chinmay MAHESHWARI , Quintus MEDLEY , Muneto MOGI , Michela MONTECCHI-PALMER , Kali STASI

IPC: A61K31/517 , A61K47/38 , A61K47/02 , A61K47/26 , A61K47/10

Abstract: The present invention provides formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I) and methods for treating ocular surface pain by administering such formulations. The present invention also provides methods for treating dry eye disease and ocular hyperemia by administering formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile.

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