发明申请
- 专利标题： METHOD FOR MODIFYING AMINO GROUP IN MOLECULE WITH THE ZOLINIUM AND USE THEREOF
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申请号： US17594199申请日： 2020-03-30
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公开(公告)号： US20220177515A1公开(公告)日： 2022-06-09
- 发明人: Bo LI , Peng LIU , Haiguo SUN , Mengyu XI , Zhijian XU , Yong ZHANG , Weiliang ZHU
- 申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- 申请人地址： CN Shanghai
- 专利权人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- 当前专利权人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- 当前专利权人地址： CN Shanghai
- 优先权： CN201910276925.1 20190408
- 国际申请： PCT/CN2020/081983 WO 20200330
- 主分类号： C07K1/13
- IPC分类号： C07K1/13 ; C07D215/38 ; C07D401/12 ; C07D217/22 ; C07K5/078 ; C07K1/113 ; C07K7/06
摘要：
The present disclosure relates to a method for modifying or marking an amino group in a molecule, wherein the amino group in the molecule is modified or marked with zolinium(s) shown in the following formula 1, wherein the molecule comprises amino acid ester, aminoamide, or peptide/protein. The method has advantages of economy and site selectivity, and has huge potential application value in the field such as pharmaceutical molecular synthesis, probe molecule and diagnostic marker reagent development.