公开(公告)号：US20220177515A1

公开(公告)日：2022-06-09

申请号：US17594199

申请日：2020-03-30

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Bo LI ,  Peng LIU ,  Haiguo SUN ,  Mengyu XI ,  Zhijian XU ,  Yong ZHANG ,  Weiliang ZHU

IPC: C07K1/13 ,  C07D215/38 ,  C07D401/12 ,  C07D217/22 ,  C07K5/078 ,  C07K1/113 ,  C07K7/06

Abstract: The present disclosure relates to a method for modifying or marking an amino group in a molecule, wherein the amino group in the molecule is modified or marked with zolinium(s) shown in the following formula 1, wherein the molecule comprises amino acid ester, aminoamide, or peptide/protein. The method has advantages of economy and site selectivity, and has huge potential application value in the field such as pharmaceutical molecular synthesis, probe molecule and diagnostic marker reagent development.