公开(公告)号：US20220177515A1

公开(公告)日：2022-06-09

申请号：US17594199

申请日：2020-03-30

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Bo LI ,  Peng LIU ,  Haiguo SUN ,  Mengyu XI ,  Zhijian XU ,  Yong ZHANG ,  Weiliang ZHU

IPC: C07K1/13 ,  C07D215/38 ,  C07D401/12 ,  C07D217/22 ,  C07K5/078 ,  C07K1/113 ,  C07K7/06

Abstract: The present disclosure relates to a method for modifying or marking an amino group in a molecule, wherein the amino group in the molecule is modified or marked with zolinium(s) shown in the following formula 1, wherein the molecule comprises amino acid ester, aminoamide, or peptide/protein. The method has advantages of economy and site selectivity, and has huge potential application value in the field such as pharmaceutical molecular synthesis, probe molecule and diagnostic marker reagent development.

公开(公告)号：US20230338510A1

公开(公告)日：2023-10-26

申请号：US18010522

申请日：2021-06-11

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Likun GONG ,  Jin REN ,  Qiuping QIN ,  Weiliang ZHU ,  Yiru LONG ,  Zhijian XU ,  Jianhua SUN ,  Tingting LIU ,  Guangyi JIN ,  Jianping ZUO ,  Wei HUANG

IPC: A61P31/14 ,  A61K39/215 ,  A61K39/00

CPC classification number: A61K39/215 ,  A61K39/4611 ,  A61K39/4613 ,  A61K39/4614 ,  A61K39/4615 ,  A61K39/464838 ,  A61P31/14 ,  A61K2039/575 ,  A61K2039/70

Abstract: Provided are a tandem epitope polypeptide vaccine for novel coronavirus and use thereof. Specifically, a vaccine polypeptide for novel coronavirus pneumonia is provided on the basis of analysis and study of the RBD sequence and structural information of the S protein of SARS-CoV-2. Said vaccine polypeptide comprises the following elements connected in series: a generic Th epitope sequence, a B cell epitope sequence and a T cell epitope sequence. The B cell epitope and the T cell epitope have an amino acid sequence from the RBM region of the S protein of SARS-CoV-2. Provided are a vaccine composition containing said vaccine polypeptide and use thereof. Experiments show that the vaccine polypeptide of the present invention can enable cynomolgus monkeys to initiate strong cellular and humoral immunity, and to generate neutralizing antibodies that block the binding of RBD and ACE2, and can be used for preventing and treating novel coronavirus pneumonia.

公开(公告)号：US20170087173A1

公开(公告)日：2017-03-30

申请号：US15126676

申请日：2015-03-17

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES ,  NANJING PAILEXING PHARMACEUTICAL TECHNOLOGY LTD.

Inventor： Weiliang ZHU ,  Heyao WANG ,  Yong ZHANG ,  Peng SUN ,  Bo LI ,  Zhijian XU ,  Hualiang JIANG ,  Kaixian CHEN

IPC: A61K31/7048 ,  A61K36/53

CPC classification number: A61K31/7048 ,  A61K36/53 ,  A61K2236/30 ,  A61K2236/53

Abstract: Disclosed is a Glechoma longituba (Nakai) Kupr. extract, specifically compounds I and II, a preparation method for same, and a use thereof in preparing a medicament for blood glucose decease, blood lipids decrease, weight loss, and kidney disease treatment or a method for treatment of said diseases, and a composition containing the extract.