公开(公告)号：US20220177515A1

公开(公告)日：2022-06-09

申请号：US17594199

申请日：2020-03-30

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Bo LI ,  Peng LIU ,  Haiguo SUN ,  Mengyu XI ,  Zhijian XU ,  Yong ZHANG ,  Weiliang ZHU

IPC: C07K1/13 ,  C07D215/38 ,  C07D401/12 ,  C07D217/22 ,  C07K5/078 ,  C07K1/113 ,  C07K7/06

Abstract: The present disclosure relates to a method for modifying or marking an amino group in a molecule, wherein the amino group in the molecule is modified or marked with zolinium(s) shown in the following formula 1, wherein the molecule comprises amino acid ester, aminoamide, or peptide/protein. The method has advantages of economy and site selectivity, and has huge potential application value in the field such as pharmaceutical molecular synthesis, probe molecule and diagnostic marker reagent development.

公开(公告)号：US20170087173A1

公开(公告)日：2017-03-30

申请号：US15126676

申请日：2015-03-17

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES ,  NANJING PAILEXING PHARMACEUTICAL TECHNOLOGY LTD.

Inventor： Weiliang ZHU ,  Heyao WANG ,  Yong ZHANG ,  Peng SUN ,  Bo LI ,  Zhijian XU ,  Hualiang JIANG ,  Kaixian CHEN

IPC: A61K31/7048 ,  A61K36/53

CPC classification number: A61K31/7048 ,  A61K36/53 ,  A61K2236/30 ,  A61K2236/53

Abstract: Disclosed is a Glechoma longituba (Nakai) Kupr. extract, specifically compounds I and II, a preparation method for same, and a use thereof in preparing a medicament for blood glucose decease, blood lipids decrease, weight loss, and kidney disease treatment or a method for treatment of said diseases, and a composition containing the extract.