Invention Application
- Patent Title: METHOD FOR MODIFYING AMINO GROUP IN MOLECULE WITH THE ZOLINIUM AND USE THEREOF
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Application No.: US17594199Application Date: 2020-03-30
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Publication No.: US20220177515A1Publication Date: 2022-06-09
- Inventor: Bo LI , Peng LIU , Haiguo SUN , Mengyu XI , Zhijian XU , Yong ZHANG , Weiliang ZHU
- Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Applicant Address: CN Shanghai
- Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Current Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Current Assignee Address: CN Shanghai
- Priority: CN201910276925.1 20190408
- International Application: PCT/CN2020/081983 WO 20200330
- Main IPC: C07K1/13
- IPC: C07K1/13 ; C07D215/38 ; C07D401/12 ; C07D217/22 ; C07K5/078 ; C07K1/113 ; C07K7/06
Abstract:
The present disclosure relates to a method for modifying or marking an amino group in a molecule, wherein the amino group in the molecule is modified or marked with zolinium(s) shown in the following formula 1, wherein the molecule comprises amino acid ester, aminoamide, or peptide/protein. The method has advantages of economy and site selectivity, and has huge potential application value in the field such as pharmaceutical molecular synthesis, probe molecule and diagnostic marker reagent development.
Information query
