- 专利标题： 5-OXOPYRROLIDINE-3-CARBOXAMIDES AS NAV1.8 INHIBITORS
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申请号： US18009310申请日： 2021-06-14
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公开(公告)号： US20230227405A1公开(公告)日： 2023-07-20
- 发明人: Ashok Arasappan , Ian M. Bell , Jason Michael Cox , Michael J. Kelly, III , Mark E. Layton , Hong Liu , Jian Liu , Akshay A. Shah , Michael David VanHeyst
- 申请人： Ashok ARASAPPAN , Ian M. BELL , Jason M. COX , Michael J. KELLY, III , Mark E. LAYTON , Hong LIU , Jian LIU , Akshay A. SHAH , Michael D. VANHEYST , MERCK SHARP & DOHME CORP.
- 申请人地址： US NJ Kenilworth
- 专利权人： Merck Sharp & Dohme LLC
- 当前专利权人： Merck Sharp & Dohme LLC
- 当前专利权人地址： US NJ Rahway
- 国际申请： PCT/US2021/037160 2021.06.14
- 进入国家日期： 2022-12-08
- 主分类号： C07D207/277
- IPC分类号： C07D207/277 ; C07D401/12 ; C07D417/12
摘要：
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.
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