利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

325 条记录 (耗时 0.059 秒)

    Iminothiadiazepane Dioxide Compounds as BACE Inhibitors, Compositions, and Their Use
    6.
    发明申请
    Iminothiadiazepane Dioxide Compounds as BACE Inhibitors, Compositions, and Their Use 有权
    作为BACE抑制剂，组合物及其用途的伊马替西二酮二氧化物化合物

    公开(公告)号：US20170037056A1

    公开(公告)日：2017-02-09

    申请号：US15104257

    申请日：2014-12-16

    申请人： Xing DAI ,  Jared N. CUMMING ,  Jack D. SCOTT ,  Hong LIU ,  Anandan PALANI ,  MERCK SHARP & DOHME CORP.

    发明人： Xing Dai ,  Jared N. Cumming ,  Jack D. Scott ,  Hong Liu ,  Anandan Palani

    IPC分类号： C07D513/04 ,  C07D471/04 ,  C07D285/36 ,  C07D417/12

    CPC分类号： C07D513/04 ,  C07D285/36 ,  C07D417/12 ,  C07D471/04

    摘要： In its many embodiments, the present invention provides certain iminothiadiazepane dioxide compounds, including compounds Formula (I): or a tautomers thereof, and pharmaceutically acceptable salts of said compounds and said tautomers, wherein RN, R1A, R1B, R2, R3, R4, ring A, RA, m, -L1-, and RL are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and may be useful for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed.

    摘要翻译： 或其互变异构体和所述化合物和所述互变异构体的药学上可接受的盐，其中RN，R1A，R1B，R2，R3，R4，环A，RA，m，-L1-和RL如本文所定义。 本发明的新化合物可用作BACE抑制剂，并且可用于治疗和预防与其相关的各种病症。 还公开了包含一种或多种这样的化合物（单独和与一种或多种其它活性剂组合）的药物组合物及其制备和使用方法，包括用于治疗阿尔茨海默氏病的药物组合物。