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公开(公告)号：US20230227405A1
公开(公告)日：2023-07-20
申请号：US18009310
申请日：2021-06-14
申请人： Ashok ARASAPPAN , Ian M. BELL , Jason M. COX , Michael J. KELLY, III , Mark E. LAYTON , Hong LIU , Jian LIU , Akshay A. SHAH , Michael D. VANHEYST , MERCK SHARP & DOHME CORP.
发明人： Ashok Arasappan , Ian M. Bell , Jason Michael Cox , Michael J. Kelly, III , Mark E. Layton , Hong Liu , Jian Liu , Akshay A. Shah , Michael David VanHeyst
IPC分类号： C07D207/277 , C07D401/12 , C07D417/12
CPC分类号： C07D207/277 , C07D401/12 , C07D417/12
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.
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公开(公告)号：US20230227441A1
公开(公告)日：2023-07-20
申请号：US18009306
申请日：2021-06-14
申请人： Ashok ARASAPPAN , Ian M. BELL , Christopher James BUNGARD , Christopher S. BURGEY , Jason M. COX , Deodial Guy GUIADEEN , Michael J. KELLY , Mark E. LAYTON , Hong LIU , Jian LIU , James T. OLSEN , James J. PERKINS , Jeffrey W. SCHUBERT , Akshay A. SHAH , Michael D. VANHEYST , Zhe WU , Shawn J. STACHEL , MERCK SHARP & DOHME CORP.
发明人： Ashok Arasappan , Ian M. Bell , Christopher James Bungard , Christopher S. Burgey , Jason Michael Cox , Deodial Guy Guiadeen, III , Michael J. Kelly, III , Mark E. Layton , Hong Liu , Jian Liu , James T. Olsen , James J. Perkins , Jeffrey W. Schubert , Akshay A. Shah , Shawn J. Stachel , Michael David VanHeyst , Zhe Wu
IPC分类号： C07D413/12 , C07D263/24 , C07D417/12
CPC分类号： C07D413/12 , C07D263/24 , C07D417/12
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.
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3.发明申请公开(公告)号：US20220089585A1
公开(公告)日：2022-03-24
申请号：US17422642
申请日：2020-01-10
申请人： Dane James CLAUSEN , Joseph A. KOZLOWSKI , Jian LIU , Scott E. WOLKENBERG , Wensheng YU , Merck Sharp & Dohme Corp.
IPC分类号： C07D413/14 , C07D413/12 , A61K45/06 , A61K31/422 , A61K31/4709 , C07D417/14 , A61P31/18
摘要： The present invention relates to Compounds of Formula I and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, R4, X and A are as defined herein. The present invention also relates to compositions comprising at least one compound of Formula I, and methods of using the compounds of Formula I for treating or preventing HIV infection in a subject.
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公开(公告)号：US11377438B2
公开(公告)日：2022-07-05
申请号：US16669598
申请日：2019-10-31
发明人： Ashok Arasappan , Ian M. Bell , Michael J. Breslin , Christopher James Bungard , Christopher S. Burgey , Harry R. Chobanian , Jason M. Cox , Anthony T. Ginnetti , Deodial Guy Guiadeen , Kristen L. G. Jones , Mark E. Layton , Hong Liu , Jian Liu , James J. Perkins , Shawn J. Stachel , Linda M. Suen-Lai , Zhe Wu
IPC分类号： C07D401/12 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04 , C07D471/08 , C07D487/04 , C07D491/048 , C07D495/04
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.
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公开(公告)号：US20210069288A1
公开(公告)日：2021-03-11
申请号：US17005686
申请日：2020-08-28
发明人： Hubert Josien , Abbas Walji , Harold B. Wood , Fa-Xiang Ding , Jian Liu , Thomas Joseph Tucker , Michael Man-Chu Lo , Liangqin Guo
摘要： Disclosed are compounds of Formula A, or a pharmaceutically acceptable salt thereof: where A, X, R1, and R2 are as defined herein, which compounds have properties for antagonizing PCSK9. Also described are pharmaceutical formulations comprising the compounds of Formula I or their salts, and methods of treating cardiovascular disease and conditions related to PCSK9 activity, e.g. atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions.
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公开(公告)号：US20190389909A1
公开(公告)日：2019-12-26
申请号：US16446940
申请日：2019-06-20
发明人： Harold B. Wood , Hubert B. Josien , Thomas Joseph Tucker , Angela Dawn Kerekes , Ling Tong , Abbas M. Walji , Anilkumar G. Nair , Fa-Xiang Ding , Elisabetta Bianchi , Danila Branca , Chengwei Wu , Yusheng Xiong , Sookhee Nicole HA , Jian Liu , Sobhana Babu Boga
摘要： Disclosed are compounds of Formula I, or a salt thereof: where A, B, D, X, R1, R2 and R8 are as defined herein, which compounds have properties for antagonizing PCSK9. Also described are pharmaceutical formulations comprising the compounds of Formula I or their salts, and methods of treating cardiovascular disease and conditions related to PCSK9 activity, e.g. atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions.
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公开(公告)号：US09718828B2
公开(公告)日：2017-08-01
申请号：US15250978
申请日：2016-08-30
发明人： Adrianus Petrus Antonius De Man , Jan-Gerard Sterrenburg , Hans C. A. Raaijmakers , Allard Kaptein , Arthur A. Oubrie , Johannes Bernardus Maria Rewinkel , Christiaan Gerardus Johannes Maria Jans , Jacobus C. H. M. Wijkmans , Tjeerd A. Barf , Alan B. Cooper , Ronald M. Kim , Sobhana Babu Boga , Hugh Y. Zhu , Xiaolei Gao , Xin Yao , Rajan Anand , Hao Wu , Shilan Liu , Chundao Yang , Abdul-Basit Alhassan , James Wang , Younong Yu , Jian Liu , Henry M. Vaccaro
IPC分类号： C07D487/04 , C07D497/02 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , A61K31/437 , A61K31/4985 , A61K31/519 , A61K31/52 , A61K31/53 , A61P19/02 , C07D519/00 , A61K45/06 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D513/04 , C07D471/04
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D471/04 , C07D513/04 , C07D519/00
摘要： Provided are 6-5 membered fused pyridine ring compounds according to Formula (I) or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these compounds and their use in therapy. In particular, provided is the use of 6-5 membered fused pyridine ring compounds in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.
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公开(公告)号：US20140378493A1
公开(公告)日：2014-12-25
申请号：US14480202
申请日：2014-09-08
发明人： Pengcheng Patrick Shao , Wanying Sun , Revathi Reddy Katipally , Petr Vachal , Feng Ye , Jian Liu , Deyou Sha
IPC分类号： C07D498/04 , A61K31/4439 , A61K45/06 , A61K31/437 , A61K31/444 , A61K31/424 , A61K31/506
CPC分类号： C07D498/04 , A61K31/424 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K45/06
摘要： Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis.
摘要翻译： 具有式I结构的化合物，包括化合物的药学上可接受的盐，是CETP抑制剂，可用于培养HDL-胆固醇，降低LDL-胆固醇，以及用于治疗或预防动脉粥样硬化。
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公开(公告)号：US11802122B2
公开(公告)日：2023-10-31
申请号：US17347639
申请日：2021-06-15
发明人： Ashok Arasappan , Ian M. Bell , Christopher James Bungard , Christopher S. Burgey , Jason M. Cox , Michael J. Kelly, III , Mark E. Layton , Hong Liu , Jian Liu , James J. Perkins , Akshay A. Shah , Michael David VanHeyst , Zhe Wu
IPC分类号： C07D403/12 , C07D233/32 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/08 , C07D513/04 , A61K31/4166 , A61P25/00 , A61P25/04 , A61P29/00
CPC分类号： C07D403/12 , C07D233/32 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/08 , C07D513/04
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.
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10.发明申请公开(公告)号：US20220144837A1
公开(公告)日：2022-05-12
申请号：US17438479
申请日：2020-03-16
发明人： Wensheng Yu , Joseph A. Kozlowski , Dane James Clausen , Jian Liu , James Fells
IPC分类号： C07D471/22 , A61P31/18 , A61K31/4748 , C07D491/18 , C07D498/22 , C07D487/08 , A61K31/438 , A61K31/426 , A61K31/635 , A61K31/4418 , A61K31/506 , A61K31/685 , A61K31/505 , A61K31/4439 , A61K31/52 , A61K31/513
摘要： The present invention relates to Compounds of Formula I and Ia and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, X, A and B are as defined herein. The present invention also relates to compositions comprising at least one compound of Formula I or Ia, and methods of using the compounds of Formula I or Ia for treating or preventing HIV infection in a subject.
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