A chip state monitoring circuit based on a self-balancing differential signal integration and amplification circuit is provided. The chip state monitoring circuit is built in a chip, and can sense a state signal of the chip and transmit the state signal to a chip configuration circuit after performing amplification and analog-to-digital conversion, such that the chip configuration circuit can monitor a state and provide a timely feedback or response, thereby improving reliability and a service life of the chip. The chip state monitoring circuit uses a brand new self-balancing differential signal integration and amplification circuit. With a built-in positive coefficient integration network and negative coefficient balancing network, the self-balancing differential signal integration and amplification circuit can perform amplification by required times to enter a self-balancing stable state, thereby achieving fixed-multiple amplification without timed reading. The control method is simple and flexible.