- 专利标题： AFFINITY PURIFICATION OF GLYCOSIDE-CLEAVING ENZYMES
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申请号： US18201392申请日： 2023-05-24
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公开(公告)号： US20230365954A1公开(公告)日： 2023-11-16
- 发明人: Brian Dwyer , Bohong Zhang , Jun Hu , Muthuraman Meiyappan , Thomas Miller , Paul McLean , Clark Pan
- 申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED
- 申请人地址： JP Osaka
- 专利权人： TAKEDA PHARMACEUTICAL COMPANY LIMITED
- 当前专利权人： TAKEDA PHARMACEUTICAL COMPANY LIMITED
- 当前专利权人地址： JP Osaka
- 主分类号： C12N9/40
- IPC分类号： C12N9/40 ; B01J20/286 ; B01J20/289 ; B01J20/32
摘要：
The invention relates to an affinity resin functionalized with small molecule inhibitors of glycoside-cleaving enzymes, e.g., α-galactosidase A (α-Gal A), glucocerebrosidase (GCB), β-galactosidase, and acid alpha-glucosidase (GAA), and a method for purifying glycoside-cleaving enzymes produced in a cell line using the small molecule inhibitor-functionalized affinity resin.
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