- 专利标题： METHOD FOR IMPROVING PRODUCTION OF STREPTOMYCES POLYKETIDE COMPOUNDS
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申请号： US17611992申请日： 2020-05-15
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公开(公告)号： US20230056311A1公开(公告)日： 2023-02-23
- 发明人: Lixin ZHANG , Weishan WANG , Shanshan LI , Zilong LI , Gaoyi TAN , Jingyu ZHANG
- 申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCES
- 申请人地址： CN Shanghai; CN Beijing
- 专利权人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY,INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCES
- 当前专利权人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY,INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCES
- 当前专利权人地址： CN Shanghai; CN Beijing
- 优先权： CN201910411123.7 20190517
- 国际申请： PCT/CN2020/090452 WO 20200515
- 主分类号： C12P13/00
- IPC分类号： C12P13/00 ; C12N15/01 ; C12N1/20 ; C12N9/02 ; C12N9/10 ; C12N9/16 ; C12P17/16 ; C12P17/18
摘要：
A method for improving the production of Streptomyces polyketide compounds is provided. The method greatly improves the capability of the Streptomyces polyketide compounds by strengthening a triacylglycerol decomposition pathway in Streptomyces during the stationary phase. A method for switching the primary metabolism of Streptomyces to the secondary metabolism, Streptomyces producing polyketide compounds, and use thereof are also provided.