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公开(公告)号:US20230056311A1
公开(公告)日:2023-02-23
申请号:US17611992
申请日:2020-05-15
申请人: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCES
发明人: Lixin ZHANG , Weishan WANG , Shanshan LI , Zilong LI , Gaoyi TAN , Jingyu ZHANG
摘要: A method for improving the production of Streptomyces polyketide compounds is provided. The method greatly improves the capability of the Streptomyces polyketide compounds by strengthening a triacylglycerol decomposition pathway in Streptomyces during the stationary phase. A method for switching the primary metabolism of Streptomyces to the secondary metabolism, Streptomyces producing polyketide compounds, and use thereof are also provided.