Invention Application
![1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS AND METHODS AND USES THEREFOR](/docs/US/2023-05-04/US20230140047A1/abs.jpg.600x600.jpg)
- Patent Title: 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS AND METHODS AND USES THEREFOR
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Application No.: US18081558Application Date: 2022-12-14
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Publication No.: US20230140047A1Publication Date: 2023-05-04
- Inventor: YAM B. POUDEL , Sanjeev GANGWAR , Liqi HE , Prasanna SIVAPRAKASAM , Matthias BROEKEMA , Matthew COX , Christine M. TARBY , Qian ZHANG , Naidu S. CHOWDARI
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Main IPC: A61K31/519
- IPC: A61K31/519 ; A61K47/60 ; A61K39/395 ; C07D487/04 ; A61P35/00 ; A61K31/395
![1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS AND METHODS AND USES THEREFOR](/abs-image/US/2023/05/04/US20230140047A1/abs.jpg.150x150.jpg)
Abstract:
Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.
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