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![1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS AND METHODS AND USES THEREFOR](/abs-image/US/2023/05/04/US20230140047A1/abs.jpg.150x150.jpg)
公开(公告)号：US20230140047A1
公开(公告)日：2023-05-04
申请号：US18081558
申请日：2022-12-14
发明人： YAM B. POUDEL , Sanjeev GANGWAR , Liqi HE , Prasanna SIVAPRAKASAM , Matthias BROEKEMA , Matthew COX , Christine M. TARBY , Qian ZHANG , Naidu S. CHOWDARI
IPC分类号： A61K31/519 , A61K47/60 , A61K39/395 , C07D487/04 , A61P35/00 , A61K31/395
摘要： Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.
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![C3-SUBSTITUTED 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS](/abs-image/US/2023/04/27/US20230127326A1/abs.jpg.150x150.jpg)
2.发明申请公开(公告)号：US20230127326A1
公开(公告)日：2023-04-27
申请号：US17792905
申请日：2021-01-26
发明人： Christine M. TARBY , Qiang CONG , Ashvinikumar V. GAVAI , Sanjeev GANGWAR , Matthias BROEKEMA , Patrice GILL , Prasanna SIVAPRAKASAM , Walter L. JOHNSON , Murugaiah Andappan Murugaiah SUBBAIAH , Yam B. POUDEL
IPC分类号： A61K31/519 , A61K39/395 , C07D487/04
摘要： Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.
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3.发明申请公开(公告)号：US20200308175A1
公开(公告)日：2020-10-01
申请号：US16902860
申请日：2020-06-16
IPC分类号： C07D473/18 , A61K47/68 , A61P37/04 , A61K47/60
摘要： Compounds having a structure according to formula (I) where R1 and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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4.发明申请公开(公告)号：US20190055244A1
公开(公告)日：2019-02-21
申请号：US16103511
申请日：2018-08-14
IPC分类号： C07D473/18
摘要： Compounds having a structure according to formula (I), (II), or (III) where R1, R2, R3, R5X1, X2, and X3 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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![1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS](/abs-image/US/2023/04/20/US20230118688A1/abs.jpg.150x150.jpg)
公开(公告)号：US20230118688A1
公开(公告)日：2023-04-20
申请号：US17792869
申请日：2021-01-26
发明人： Heng CHENG , Christine M. TARBY , Sanjeev GANGWAR , Ashvinikumar V. GAVAI , Walter L. JOHNSON , Yam B. POUDEL , Prasanna SIVAPRAKASAM , Patrice GILL , Andrew F. DONNELL , Murugaiah Andappan Murugaiah SUBBAIAH
IPC分类号： A61K31/519 , C07D487/04 , A61K39/395
摘要： Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.
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公开(公告)号：US20210053979A1
公开(公告)日：2021-02-25
申请号：US17043886
申请日：2019-04-23
发明人： Ashok V. PURANDARE , Honghe WAN , Liqi HE , Sanjeev GANGWAR , Shoshana L. POSY , Yam B. POUDEL , Prasanna SIVAPRAKASAM , Naidu S. CHOWDARI
IPC分类号： C07D487/16 , A61K47/60
摘要： Compounds having a structure according to formula are modulators of TLR7 activity and can be used to treat conditions amenable to treatment by the modulation of TLR7 activity.
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公开(公告)号：US20200095248A1
公开(公告)日：2020-03-26
申请号：US16676870
申请日：2019-11-07
发明人： Liqi HE , Sanjeev GANGWAR , Yam B. POUDEL , Prasanna SIVAPRAKASAM
IPC分类号： C07D473/18 , A61P37/04
摘要： Compounds having a structure according to formula (I) or (II) where R1, R2, R3, R4, Ar and X1 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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![1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS AND METHODS AND USES THEREFOR](/abs-image/US/2020/02/06/US20200038403A1/abs.jpg.150x150.jpg)
8.发明申请公开(公告)号：US20200038403A1
公开(公告)日：2020-02-06
申请号：US16527802
申请日：2019-07-31
发明人： Yam B. POUDEL , Sanjeev GANGWAR , Liqi HE , Prasanna SIVAPRAKASAM , Matthias BROEKEMA , Matthew COX , Christine M. TARBY , Qian ZHANG
IPC分类号： A61K31/519 , C07D487/04 , A61K39/395 , A61K47/60
摘要： Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.
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公开(公告)号：US20180110873A1
公开(公告)日：2018-04-26
申请号：US15789027
申请日：2017-10-20
发明人： Ivar M. MCDONALD , Prasanna SIVAPRAKASAM , Christiana I. IWUAGWU , Kevin M. Peese , Heng CHENG , Naidu S. CHOWDARI , Sanjeev GANGWAR
IPC分类号： A61K47/68 , C07F7/08 , C07K5/062 , C07D471/04 , C07D519/00
CPC分类号： A61K47/6803 , C07D471/04 , C07D519/00 , C07F7/0814 , C07K5/06026
摘要： A compound capable of inhibiting cell proliferation, having a structure according to formula (I) wherein the variables in formula (I) are as defined in the specification. Such compounds are useful as anti-cancer agents, especially in antibody-drug conjugates.
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![1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS](/abs-image/US/2023/05/11/US20230144824A1/abs.jpg.150x150.jpg)
公开(公告)号：US20230144824A1
公开(公告)日：2023-05-11
申请号：US17793248
申请日：2021-01-26
发明人： Liqi HE , Ashvinikumar V. GAVAI , Sanjeev GANGWAR , Qiang CONG , Yam B. POUDEL , Prasanna SIVAPRAKASAM , Christine M. TARBY , Patrice GILL , Andrew F. DONNELL , Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Compounds according to formula I or II are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.
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