公开(公告)号：US20230140047A1

公开(公告)日：2023-05-04

申请号：US18081558

申请日：2022-12-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： YAM B. POUDEL ,  Sanjeev GANGWAR ,  Liqi HE ,  Prasanna SIVAPRAKASAM ,  Matthias BROEKEMA ,  Matthew COX ,  Christine M. TARBY ,  Qian ZHANG ,  Naidu S. CHOWDARI

IPC: A61K31/519 ,  A61K47/60 ,  A61K39/395 ,  C07D487/04 ,  A61P35/00 ,  A61K31/395

Abstract: Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20230140430A1

公开(公告)日：2023-05-04

申请号：US17792887

申请日：2021-01-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Matthew COX ,  Liqi HE ,  Sanjeev GANGWAR ,  Ashvinikumar V. GAVAI ,  Matthias BROEKEMA ,  Qiang CONG ,  Daniel O'MALLEY ,  Yam B. POUDEL ,  Christine M. TARBY

IPC: C07D519/00 ,  A61K45/06

Abstract: Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20200308175A1

公开(公告)日：2020-10-01

申请号：US16902860

申请日：2020-06-16

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yam B. POUDEL ,  Liqi HE ,  Sanjeev GANGWAR ,  Shoshana L. POSY ,  Prasanna SIVAPRAKASAM

IPC: C07D473/18 ,  A61K47/68 ,  A61P37/04 ,  A61K47/60

Abstract: Compounds having a structure according to formula (I) where R1 and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

公开(公告)号：US20210053979A1

公开(公告)日：2021-02-25

申请号：US17043886

申请日：2019-04-23

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ashok V. PURANDARE ,  Honghe WAN ,  Liqi HE ,  Sanjeev GANGWAR ,  Shoshana L. POSY ,  Yam B. POUDEL ,  Prasanna SIVAPRAKASAM ,  Naidu S. CHOWDARI

IPC: C07D487/16 ,  A61K47/60

Abstract: Compounds having a structure according to formula are modulators of TLR7 activity and can be used to treat conditions amenable to treatment by the modulation of TLR7 activity.

公开(公告)号：US20200095248A1

公开(公告)日：2020-03-26

申请号：US16676870

申请日：2019-11-07

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Liqi HE ,  Sanjeev GANGWAR ,  Yam B. POUDEL ,  Prasanna SIVAPRAKASAM

IPC: C07D473/18 ,  A61P37/04

Abstract: Compounds having a structure according to formula (I) or (II) where R1, R2, R3, R4, Ar and X1 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

公开(公告)号：US20200038403A1

公开(公告)日：2020-02-06

申请号：US16527802

申请日：2019-07-31

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yam B. POUDEL ,  Sanjeev GANGWAR ,  Liqi HE ,  Prasanna SIVAPRAKASAM ,  Matthias BROEKEMA ,  Matthew COX ,  Christine M. TARBY ,  Qian ZHANG

IPC: A61K31/519 ,  C07D487/04 ,  A61K39/395 ,  A61K47/60

Abstract: Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20230144824A1

公开(公告)日：2023-05-11

申请号：US17793248

申请日：2021-01-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Liqi HE ,  Ashvinikumar V. GAVAI ,  Sanjeev GANGWAR ,  Qiang CONG ,  Yam B. POUDEL ,  Prasanna SIVAPRAKASAM ,  Christine M. TARBY ,  Patrice GILL ,  Andrew F. DONNELL ,  Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: Compounds according to formula I or II are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20230130516A1

公开(公告)日：2023-04-27

申请号：US17792878

申请日：2021-01-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Qian ZHANG ,  Sanjeev GANGWAR ,  Ashvinikumar V. GAVAI ,  Qiang CONG ,  Yam B. POUDEL ,  Liqi HE ,  Prasanna SIVAPRAKASAM ,  Christine M. TARBY

IPC: A61K31/519 ,  C07D487/04 ,  C07D519/00 ,  A61K31/5377 ,  A61K39/395

Abstract: Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20200048254A1

公开(公告)日：2020-02-13

申请号：US16659735

申请日：2019-10-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Liqi HE ,  Sanjeev GANGWAR ,  Shoshana L. POSY ,  Yam B. POUDEL ,  Prasanna SIVAPRAKASAM

IPC: C07D473/18 ,  A61K31/52 ,  A61K47/68 ,  A61K47/60 ,  A61P37/04

Abstract: Compounds having a structure according to formula (I) or (II) where R1, R2, and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

公开(公告)号：US20190055247A1

公开(公告)日：2019-02-21

申请号：US16103619

申请日：2018-08-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Liqi HE ,  Sanjeev GANGWAR ,  Yam B. POUDEL ,  Prasanna SIVAPRAKASAM

IPC: C07D473/18

Abstract: Compounds having a structure according to formula (I) or (II) where R1, R2, R3, R4, Ar and X1 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.