A modular endoscope system comprises a first modular section comprising imaging and illumination units, and a patient-insertable second modular section that can be detached to the first modular section via an attachment mechanism, wherein the first modular section is positionable at a distal end section of the second modular section and is configured to illuminate and image a portion of a patient anatomy. A method of using a modular endoscopy system comprises attaching a first modular section of the modular endoscopy system to a second modular section of the modular endoscopy system, positioning at least a portion of the modular endoscopy system within a patient, illuminating and imaging a portion of a patient anatomy via the first modular section, removing the modular endoscopy system from the patient, and detaching the second modular section from the first modular section after removal of the modular endoscopy system from the patient.