发明授权
- 专利标题: Sesquiterpene derivatives having anti-complementary activity
- 专利标题(中): 倍半萜衍生物具有抗互补活性
-
申请号: US906300申请日: 1978-05-15
-
公开(公告)号: US4229466A公开(公告)日: 1980-10-21
- 发明人: Wasei Miyazaki , Hirotsugu Kaise , Yoshimasa Nakano , Taketoshi Izawa , Yasuo Oshiro , Masanao Shinohara
- 申请人: Wasei Miyazaki , Hirotsugu Kaise , Yoshimasa Nakano , Taketoshi Izawa , Yasuo Oshiro , Masanao Shinohara
- 申请人地址: JPX Tokyo
- 专利权人: Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人: Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX52-78641 19770630; JPX52-158959 19771229; JPX53-14674 19780210
- 主分类号: C07D307/94
- IPC分类号: C07D307/94 ; C07D493/10 ; C07D493/20 ; C12P17/04 ; A61K31/335 ; A61K31/34 ; C07D307/77 ; C07D307/92
摘要:
A sesquiterpene derivative expressed by the general formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or a lower alkanoyl group; R.sup.2 and R.sup.3, which may be the same or different, each represents a formyl group, a hydroxymethyl group, a hydroxyl group, a carboxyl group, a lower alkanoyloxymethyl group, or a group of the formula --CH.dbd.CR.sup.7 R.sup.8, wherein R.sup.7 and R.sup.8, which may be the same or different, each represents a hydrogen atom, a cyano group, a lower alkoxycarbonyl group or a carboxyl group, or R.sup.2 and R.sup.3 may combine to form a lactone ring of the formula ##STR2## in which R.sup.9 represents a hydrogen atom or a hydroxyl group; R.sup.4 and R.sup.6, which may be the same or different, each represents a hydroxyl group or a lower alkanoyloxy group; R.sup.5 represents a hydrogen atom; R.sup.4 and R.sup.5 may together form an oxo group (.dbd.O); and R.sup.4 and R.sup.6 may combine to form a lower alkylidenedioxy group, the pharmaceutically acceptable salts thereof, processes for the production of the compounds of the general formula (I) and the salts thereof, pharmaceutical composition containing the compounds of the general formula (I) and the salts thereof, and method of use of the compounds of the general formula (I) and the salts thereof.