发明授权
US4550115A Certain piperidino-lower-alkylene esters of
3-methylflavone-8-carboxylates possessing smooth muscle relaxant
activity
失效
3-甲基黄酮-8-羧酸酯的某些哌啶子基 - 低级亚烷基酯具有平滑肌松弛剂活性
- 专利标题： Certain piperidino-lower-alkylene esters of 3-methylflavone-8-carboxylates possessing smooth muscle relaxant activity
- 专利标题（中）： 3-甲基黄酮-8-羧酸酯的某些哌啶子基 - 低级亚烷基酯具有平滑肌松弛剂活性
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申请号： US397196申请日： 1982-07-12
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公开(公告)号： US4550115A公开(公告)日： 1985-10-29
- 发明人: Dante Nardi , Alberto Tajana , Renzo Pennini , Pietro Cazzulani , Gabriele Graziani , Silvano Casadio
- 申请人： Dante Nardi , Alberto Tajana , Renzo Pennini , Pietro Cazzulani , Gabriele Graziani , Silvano Casadio
- 申请人地址： CHX Chiasso
- 专利权人： Recordati S.A., Chemical & Pharmaceutical Company
- 当前专利权人： Recordati S.A., Chemical & Pharmaceutical Company
- 当前专利权人地址： CHX Chiasso
- 优先权： GBX8122158 19810717
- 主分类号： C07D405/12
- IPC分类号： C07D405/12 ; A61K31/435 ; A61K31/443 ; A61K31/445 ; A61K31/46 ; A61P3/00 ; A61P3/14 ; A61P21/02 ; A61P23/02 ; A61P25/02 ; A61P29/00 ; C07D311/00 ; C07D311/30 ; C07D407/12 ; C07D451/02 ; C07D451/12 ; C07D453/02
摘要：
Novel 3-methylflavone-8-carboxylates having the structural formula (I): ##STR1## wherein Z is N-methylpiperidinyl, tropinyl or quinuclidinyl, or a group having the structural formula (II): ##STR2## in which n is 0 or 1, R is hydrogen or alkyl having from 1 to 4 carbon atoms, or phenyl, R.sub.1 is hydrogen or alkyl having from 1 to 4 carbon atoms, R.sub.2 is hydrogen or hydroxy, and further wherein R, R.sub.1 and R.sub.2 may together form, with the carbon atoms from which they depend, a cycloalkyl ring having from 4 to 6 carbon atoms, and R.sub.3 is hydrogen or alkyl having from 1 to 4 carbon atoms, with the proviso that R, R.sub.1, R.sub.2 and R.sub.3 cannot at the same time all be hydrogen, and the pharmaceutically acceptable salts thereof, are effective smooth muscle relaxants, calcium blockers, anaesthetics and anti-inflammatories.