-
1.发明授权Analgesically or anti-inflammatory effective 4-quinolyl anthranilic acid derivatives 失效止痛或消炎有效的4-喹啉基邻氨基苯甲酸衍生物
公开(公告)号：US4507308A
公开(公告)日：1985-03-26
申请号：US426229
申请日：1982-09-28
申请人： Dante Nardi , Gianni Motta , Rodolfo Testa , Gabriele Graziani , Silvano Casadio
发明人： Dante Nardi , Gianni Motta , Rodolfo Testa , Gabriele Graziani , Silvano Casadio
IPC分类号： C07D215/44 , A61K31/47 , A61P25/04 , A61P29/00 , C07D405/12 , C07D413/12
CPC分类号： C07D405/12 , C07D413/12
摘要： The novel anthranilic acid derivatives having the structural formula (I): ##STR1## wherein n is 0, 1 or 2, one of R.sub.1 and R.sub.2 is chloro or trifluoromethyl and the other is hydrogen, and R is 2-oxo-3-oxolanyl or 2-oxo-3-oxazolidinyl, are effective analgesics and anti-inflammatories.
摘要翻译： 具有结构式（I）的新型邻氨基苯甲酸衍生物：其中n为0,1或2，R 1和R 2中的一个为氯或三氟甲基，另一个为氢，R为2-氧代-3-氧杂环戊烷基 或2-氧代-3-恶唑烷基，是有效的止痛剂和抗炎药。
-
2.发明授权Dioxolanic amine with pharmacological activity, its method of preparation, the pharmaceutical compositions containing same and their use in human medicine 失效具有药理活性的二氧戊环胺，其制备方法，含有它们的药物组合物及其在人类药物中的用途
公开(公告)号：US4495199A
公开(公告)日：1985-01-22
申请号：US432397
申请日：1982-09-30
IPC分类号： C07D407/04 , A61K31/34 , C07D317/00
CPC分类号： C07D407/04
摘要： A new dioxolanic amine is disclosed, with pharmacological activity of the following structural formula I: ##STR1## as well as its pharmaceutically acceptable salts, possessing intense vasodilatory, anti-angina and anti-arrhythmic activity, accompanied by a low toxicity; its method of preparation; pharmaceutical compositions containing the said compounds; and the treatment and prevention various pathological conditions with the use of said compositions. Also disclosed are new dioxolanic compound of the following structural formula II: ##STR2## which is an intermediate compound in the preparation of the formula I compound; and its method of preparation.
摘要翻译： 公开了一种新的二氧戊环胺，其具有以下结构式I的药理学活性：其具有强烈的血管舒张，抗心绞痛和抗心律不齐活性，伴有低毒性的药学上可接受的盐; 其制备方法; 含有所述化合物的药物组合物; 以及使用所述组合物治疗和预防各种病理状况。 还公开了以下结构式II的新二氧戊环化合物：作为式I化合物的制备中的中间体化合物： 及其制备方法。
-
公开(公告)号：US4243679A
公开(公告)日：1981-01-06
申请号：US31612
申请日：1979-04-19
IPC分类号： A61K31/195 , A61K20060101 , A61K31/198 , A61P11/10 , C07C20060101 , C07C67/00 , C07C313/00 , C07C323/58
CPC分类号： A61K31/195
摘要： S-(3-methyl-2-butenyl)cysteine ##STR1## or a pharmaceutically acceptable salt thereof. The compound is an expectorant and can be applied in the form of capsules or dragees, solutions, syrups or suppositories.
摘要翻译： S-（3-甲基-2-丁烯基）半胱氨酸或其药学上可接受的盐。 该化合物是祛痰剂，可以胶囊或糖衣丸，溶液剂，糖浆剂或栓剂的形式使用。
-
4.发明授权
公开(公告)号：US5019579A
公开(公告)日：1991-05-28
申请号：US445106
申请日：1989-12-07
申请人： Piero Del Soldato , Silvano Casadio
发明人： Piero Del Soldato , Silvano Casadio
IPC分类号： A61K9/00 , A61K31/485
CPC分类号： A61K31/485 , A61K9/0043 , Y10S514/947
摘要： The object of the invention is a pharmaceutically acceptable composition suitable to achieve a systemic therapeutical response due to its antitussis action in warm-blooded animals, characterized in that it contains, per dosage unit: (I) an amount therapeutically efficacious by systemic way due to the antitussis action of salified dextrorphan, and (II) a pharmaceutically non-toxic excipient acceptable for intranasal administering.
摘要翻译： 本发明的目的是一种药学上可接受的组合物，其适用于由于其在温血动物中的镇咳作用而实现全身治疗反应，其特征在于每剂量单位含有：（I）由于 盐化右旋的镇咳作用，和（II）可用于鼻内给药的药学上无毒的赋形剂。
-
5.发明授权
公开(公告)号：US4122199A
公开(公告)日：1978-10-24
申请号：US714764
申请日：1976-08-16
IPC分类号： C07D279/30 , C07D295/13 , C07D311/12 , C07D311/84 , A61K31/40
CPC分类号： C07D295/13 , C07D279/30 , C07D311/12 , C07D311/84 , Y10S514/849
摘要： New chemical compounds, which are pyrrolidinoethylamine amides, in the form of free bases and salts thereof, which are useful as antitussives, pharmaceutical compositions thereof, and method of treating therewith.In the form of their salts, the compounds have the formula: ##STR1## wherein ##STR2## is an acyl radical of a phenylacetic, 60 -phenyl-.alpha.-(1 to 5 C atoms) acetic, (1 to 5 C atoms) diphenylacetic, benzilic, diphenyl-.alpha.-chloroacetic, .alpha.-lower-alkoxy-.alpha.,.alpha.-diphenylacetic, 3-coumarincarboxylic, 9-xanthenecarboxylic, phenoxyacetic, phenoxyisobutyric, halophenoxyisobutyric, or 9-flourene carboxylic acid, and wherein R'H represents an inorganic or organic acid.Medicaments containing these active principles may be used, inter alia, in the treatment of coughs and respiratory complaints.
摘要翻译： 新的化合物，它们是吡咯烷基乙胺酰胺，其形式为游离碱和盐，它们可用作镇咳药，其药物组合物及其处理方法。
-
公开(公告)号：US3952108A
公开(公告)日：1976-04-20
申请号：US490266
申请日：1974-07-22
申请人： Silvano Casadio , Arturo Donetti
发明人： Silvano Casadio , Arturo Donetti
IPC分类号： C07D451/10 , A61K31/46
CPC分类号： C07D451/10 , Y10S514/925
摘要： The specification describes quaternary bromides of scopolamine in which the substituent on the nitrogen atom has the formula --(CH.sub.2).sub.n -R in which R represents a cycloalkyl group containing up to six carbon atoms, an alkyl-substituted cycloalkyl group containing up to six carbon atoms or an epoxyethyl group and n is 1 or 2. Such compounds have valuable spasmolytic and anti-ulcer properties and pharmaceutical preparations containing them are also described.
摘要翻译： 该说明书描述了东莨菪碱的四溴化物，其中氮原子上的取代基具有式 - （CH 2）n R，其中R表示含有至多6个碳原子的环烷基，含有至多6个碳原子的烷基取代的环烷基或 环氧乙基，n为1或2.这些化合物具有有价值的解痉和抗溃疡性质，还描述了含有它们的药物制剂。
-
7.发明授权Certain piperidino-lower-alkylene esters of 3-methylflavone-8-carboxylates possessing smooth muscle relaxant activity 失效3-甲基黄酮-8-羧酸酯的某些哌啶子基 - 低级亚烷基酯具有平滑肌松弛剂活性
公开(公告)号：US4550115A
公开(公告)日：1985-10-29
申请号：US397196
申请日：1982-07-12
申请人： Dante Nardi , Alberto Tajana , Renzo Pennini , Pietro Cazzulani , Gabriele Graziani , Silvano Casadio
发明人： Dante Nardi , Alberto Tajana , Renzo Pennini , Pietro Cazzulani , Gabriele Graziani , Silvano Casadio
IPC分类号： C07D405/12 , A61K31/435 , A61K31/443 , A61K31/445 , A61K31/46 , A61P3/00 , A61P3/14 , A61P21/02 , A61P23/02 , A61P25/02 , A61P29/00 , C07D311/00 , C07D311/30 , C07D407/12 , C07D451/02 , C07D451/12 , C07D453/02
CPC分类号： C07D407/12 , C07D311/30 , C07D451/12 , C07D453/02
摘要： Novel 3-methylflavone-8-carboxylates having the structural formula (I): ##STR1## wherein Z is N-methylpiperidinyl, tropinyl or quinuclidinyl, or a group having the structural formula (II): ##STR2## in which n is 0 or 1, R is hydrogen or alkyl having from 1 to 4 carbon atoms, or phenyl, R.sub.1 is hydrogen or alkyl having from 1 to 4 carbon atoms, R.sub.2 is hydrogen or hydroxy, and further wherein R, R.sub.1 and R.sub.2 may together form, with the carbon atoms from which they depend, a cycloalkyl ring having from 4 to 6 carbon atoms, and R.sub.3 is hydrogen or alkyl having from 1 to 4 carbon atoms, with the proviso that R, R.sub.1, R.sub.2 and R.sub.3 cannot at the same time all be hydrogen, and the pharmaceutically acceptable salts thereof, are effective smooth muscle relaxants, calcium blockers, anaesthetics and anti-inflammatories.
摘要翻译： 具有结构式（I）的新型3-甲基黄酮-8-羧酸酯：其中Z是N-甲基哌啶基，叔丁酰基或奎宁环基或具有结构式（II）的基团：其中（I） 其中n为0或1，R为氢或具有1至4个碳原子的烷基，或苯基，R 1为氢或具有1至4个碳原子的烷基，R 2为氢或羟基，并且其中R，R 1和 R2可以与它们所依赖的碳原子一起形成具有4至6个碳原子的环烷基环，并且R 3是氢或具有1至4个碳原子的烷基，条件是R，R 1，R 2和R 3 不能同时全部为氢，其药学上可接受的盐为有效的平滑肌松弛剂，钙阻滞剂，麻醉剂和抗炎剂。
-
8.发明授权
公开(公告)号：US4246271A
公开(公告)日：1981-01-20
申请号：US48371
申请日：1979-06-14
IPC分类号： C07D277/20 , A61K31/425 , A61K31/426 , A61P11/00 , A61P27/16 , A61P37/08 , C07D277/40 , C07D277/46 , C07D277/38
CPC分类号： A61K31/425 , C07D277/40 , C07D277/46 , Y10S514/826
摘要： The present invention relates to new derivatives of 4-phenyl-2-thiazolyl oxamates having the formula: ##STR1## in which: X represents hydrogen, halogen, lower-alkyl, or lower-alkoxy.R is lower-alkyl or phenyllower-alkyl, e.g., benzyl.These compounds, which have inhibiting properties on the passive cutaneous anaphylactic reaction, are useful in the treatment of asthma. Pharmaceutical compositions thereof and method of treating therewith.
摘要翻译： 本发明涉及具有下式的4-苯基-2-噻唑基恶唑烷的新衍生物：其中：X表示氢，卤素，低级烷基或低级烷氧基。 R是低级烷基或苯基低级烷基，例如苄基。 这些对被动皮肤过敏反应具有抑制性质的化合物可用于治疗哮喘。 其药物组合物及其处理方法。
-
9.发明授权New 8-substituted nucleoside and purine derivatives, the process for the preparation thereof and the pharmaceutical compositions containing them 失效新的8-取代的核苷和嘌呤衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US4774325A
公开(公告)日：1988-09-27
申请号：US776472
申请日：1985-09-16
申请人： Silvano Casadio , Duccio Favara , Amedeo Omodei-Sale , Ezio Panto
发明人： Silvano Casadio , Duccio Favara , Amedeo Omodei-Sale , Ezio Panto
IPC分类号： C07D473/34 , A61K31/52 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61K31/708 , A61P3/06 , C07D303/22 , C07D309/12 , C07D473/16 , C07D473/18 , C07F9/6561 , C07H19/16 , C07H19/167 , C07H19/20
CPC分类号： C07D303/22 , C07D309/12 , C07D473/18 , C07H19/16 , C07H19/20
摘要： New 8-substituted nucleoside and purine derivatives of the general formula: ##STR1## wherein R represents an amino group or an hydroxy group possibly in the corresponding keto tautomeric form, R.sub.1 is hydrogen or an amino group, R.sub.2 is hydrogen or a .beta.-D-ribofuranosyl radical wherein the primary hydroxy group and/or the two secondary hydroxy groups may be derivatized, R.sub.3 is an optionally substituted aryl or monocyclic heteroaryl radical and, X is --O-- or --S--. The new compounds have antihyperlipaemic activity.
摘要翻译： 新的8-取代的核苷和嘌呤衍生物，其通式如下：其中R表示氨基或可能具有相应的酮互变异构形式的羟基，R 1是氢或氨基，R 2是氢或β-D - 呋喃核糖基，其中伯羟基和/或两个仲羟基可以被衍生化，R 3是任选取代的芳基或单环杂芳基，并且X是-O-或-S-。 新化合物具有抗高血脂活性。
-
公开(公告)号：US4225610A
公开(公告)日：1980-09-30
申请号：US952739
申请日：1978-10-19
IPC分类号： C07D277/20 , A61K31/425 , A61K31/426 , A61K31/455 , A61P29/00 , A61P35/00 , A61P37/04 , C07D277/40 , C07D277/44 , C07D277/46 , C07D277/48 , C07D417/12
CPC分类号： C07D277/40 , C07D277/46 , C07D277/48 , Y10S514/825
摘要： The present invention concerns new derivatives of 4-phenyl 2-amino thiazole of the formula ##STR1## in which X represents a hydrogen atom, a halogen, a lower alkyl or an alkoxy,R is a hydrogen, a haloalkoxy, a substituted or unsubstituted aryl, a pyridyl, an aryloxy or a carboxy alkyl, having immunomodulating properties, useful in the treatment of rheumatoid arthritis and other ailments requiring immunotherapy.
摘要翻译： 本发明涉及式“IMAGE”的4-苯基-2-氨基噻唑的新衍生物，其中X表示氢原子，卤素，低级烷基或烷氧基，R为氢，卤代烷氧基，取代或未取代的 芳基，吡啶基，芳氧基或羧基烷基，具有免疫调节特性，可用于治疗类风湿性关节炎和其它需要免疫治疗的疾病。
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.012 秒)
