发明授权
US4614616A Process for preparing 3.beta.7.beta.-dihydroxy-.DELTA..sup.5 -steroids
失效
制备3β7β-二羟基-DTATA5-类固醇的方法
- 专利标题: Process for preparing 3.beta.7.beta.-dihydroxy-.DELTA..sup.5 -steroids
- 专利标题(中): 制备3β7β-二羟基-DTATA5-类固醇的方法
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申请号: US536076申请日: 1983-09-26
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公开(公告)号: US4614616A公开(公告)日: 1986-09-30
- 发明人: Karl Petzoldt , Rudolf Wiechert , Henry Laurent , Klaus Nickisch , Dieter Bittler
- 申请人: Karl Petzoldt , Rudolf Wiechert , Henry Laurent , Klaus Nickisch , Dieter Bittler
- 申请人地址: DEX Berlin and Bergkamen
- 专利权人: Schering Aktiengesellschaft
- 当前专利权人: Schering Aktiengesellschaft
- 当前专利权人地址: DEX Berlin and Bergkamen
- 优先权: DEX3042136 19801103
- 主分类号: C07J21/00
- IPC分类号: C07J21/00 ; C07J53/00 ; C07J71/00 ; C12P33/06 ; C12P33/20 ; C12R1/645 ; C07J1/00
摘要:
A process for preparing a 3.beta.,7.beta.-dihydroxy-.DELTA..sup.5 -steroid of the formula ##STR1## wherein Q is ##STR2## and R.sub.1 is hydrogen, trimethylacetyl, tert-butyldimethylsilyl, dimethyl-2-(3-methylbutyl)silyl or tribenzylsilyl, comprises fermenting a 3.beta.-hydroxy-.DELTA..sup.5 -steroid of the formula ##STR3## wherein Q is as defined above, andR.sub.2 is hydrogen or alkanoyl of 2-6 carbon atoms, with a culture of Botryodiplodia malorum to obtain the corresponding 3.beta.,7.beta.-dihydroxy-.DELTA..sup.5 -steroid; and, optionally, reacting the resultant product with trimethylacetic anhydride, tert-butyldimethylsilyl chloride, dimethyl-2-(3-methylbutyl)silyl chloride, or tribenzylsilyl chloride.