发明授权
- 专利标题： Disease diagnosis by detection of shed normal tissue antigens
- 专利标题（中）： 通过检测脱落正常组织抗原的疾病诊断
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申请号： US616991申请日： 1984-06-04
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公开(公告)号： US4731326A公开(公告)日： 1988-03-15
- 发明人: Russell E. Thompson , Robert H. Rubin , Nina T. Rubin , Teresa H. Chan
- 申请人： Russell E. Thompson , Robert H. Rubin , Nina T. Rubin , Teresa H. Chan
- 申请人地址： NJ Raritan
- 专利权人： Ortho Diagnostic Systems Inc.
- 当前专利权人： Ortho Diagnostic Systems Inc.
- 当前专利权人地址： NJ Raritan
- 主分类号： G01N33/574
- IPC分类号： G01N33/574 ; G01N33/68 ; G01N33/535 ; G01N33/545 ; G01N33/577
摘要：
Methods are provided for the detection of proximal convoluted tubule causing diseases or kidney harmful drug monitoring by detecting the presence of shed normal proximal tubule associated antigens in a body fluid such as urine. The preferred embodiment employs an ELISA sandwich format wherein one monoclonal antibody specific for a first epitopic site on said antigen is immobilized on a solid phase and a second antibody, specific for a second epitopic site on said antigen is directly or indirectly labeled.
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