发明授权
US4778796A .omega.-(3-pyridyl)alkenamide derivatives and anti-allergenic
pharmaceutical compositions containing same
失效
ω-(3-吡啶基)烯酰胺衍生物和含有其的抗过敏药物组合物
- 专利标题: .omega.-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same
- 专利标题(中): ω-(3-吡啶基)烯酰胺衍生物和含有其的抗过敏药物组合物
-
申请号: US884717申请日: 1986-07-11
-
公开(公告)号: US4778796A公开(公告)日: 1988-10-18
- 发明人: Hitoshi Uno , Yoshinori Nishikawa , Tokuhiko Shindo , Hideo Nakamura , Katsumi Ishii
- 申请人: Hitoshi Uno , Yoshinori Nishikawa , Tokuhiko Shindo , Hideo Nakamura , Katsumi Ishii
- 申请人地址: JPX
- 专利权人: Dainippon Pharmaceutical Co., Ltd.
- 当前专利权人: Dainippon Pharmaceutical Co., Ltd.
- 当前专利权人地址: JPX
- 优先权: JPX60-160783 19850719
- 主分类号: A61K31/44
- IPC分类号: A61K31/44 ; A61K31/4402 ; A61K31/4406 ; A61K31/4409 ; A61K31/4418 ; A61K31/4427 ; A61K31/455 ; A61K31/495 ; A61P7/02 ; A61P37/08 ; A61P43/00 ; C07D213/30 ; C07D213/48 ; C07D213/55 ; C07D213/56 ; C07D213/57 ; C07D213/59 ; C07D213/61 ; C07D213/62 ; C07D213/64 ; C07D213/643 ; C07D213/65 ; C07D213/70 ; C07D213/72 ; C07D213/74 ; C07D213/80 ; C07D213/84 ; C07D213/87 ; C07D213/89 ; C07D215/14 ; C07D215/38 ; C07D215/60 ; C07D243/00 ; C07D401/12 ; C07D403/06 ; C12N9/99 ; C07D401/14
摘要:
Compounds of the formula: ##STR1## wherein X is alkylene or --(CR.sub.6 .dbd.CR.sub.7).sub.r -- wherein R.sub.6 is H, alkyl or phenyl, R.sub.7 is H, alkyl, cyano or phenyl, and r is 1 or 2; A is alkylene or alkylene interrupted by at least one double bond; R.sub.1 is H, halogen, alkyl, alkoxy, alkylthio, cycloalkyloxy, cycloalkylthio, alkoxycarbonyl, carboxy, phenyl, phenoxy, phenylthio, 3-pyridyloxy or 3-pyridylthio; R.sub.2 is H, hydroxy, alkanoyloxy or alkoxycarbonyloxy, or adjacent R.sub.1 and R.sub.2 may combine to form tetramethylene or --CH.sub.2 OCR.sub.8 R.sub.9 O-- (R.sub.8 and R.sub.9 are alkyl); R.sub.3 is H, alkyl or hydroxyalkyl; R.sub.4 is H or alkyl; R.sub.5 is phenyl, heteroaryl or --(CH.sub.2).sub.m --CHR.sub.10 R.sub.11 (R.sub.10 is H or phenyl, R.sub.11 is phenyl or pyridyl and m is 0 to 2); p is 0 or 1; and q is 2 or 3; the phenyl group or moiety being optionally substituted, and a salt thereof, process for the preparation thereof, and pharmaceutical composition containing the same. Said compounds and salts thereof show excellent antiallergic activity mainly through 5-lipoxygenase inhibiting activity, antihistamine activity and/or inhibitory activity against chemical mediator release and useful for treatment of allergic diseases.
公开/授权文献
- US5927036A Floor joist system 公开/授权日:1999-07-27
信息查询