发明授权
- 专利标题： Process for preparing 1-hydroxyalkyl-5-nitroimidazoles
- 专利标题（中）： 1-羟基烷基-5-硝基咪唑的制备方法
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申请号： US296710申请日： 1989-01-13
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公开(公告)号： US4925952A公开(公告)日： 1990-05-15
- 发明人: Viviane Massonneau , Michel Mulhauser , Albert Buforn , Bernadette Mandard-Cazin
- 申请人： Viviane Massonneau , Michel Mulhauser , Albert Buforn , Bernadette Mandard-Cazin
- 申请人地址： FRX Antony
- 专利权人： Rhone-Poulenc Sante
- 当前专利权人： Rhone-Poulenc Sante
- 当前专利权人地址： FRX Antony
- 优先权： FRX8800415 19880115
- 主分类号： C07D233/92
- IPC分类号： C07D233/92 ; A61K31/4164 ; A61P33/02 ; C07D233/94 ; C07D233/95 ; C07D405/04 ; C07D405/06
摘要：
Process for preparing 1-(hydroxyalkyl)nitroimidazoles of formula: ##STR1## which comprises reacting an alkylene sulphate of formula: ##STR2## with an imidazole derivative of formula: ##STR3## followed by hydrolyzing or alcoholyzing the product obtained. In the formulae (I) and (II), n is 2 or 3; in the formulae (I) and (III), R denotes hydrogen or hydrocarbon radical; and in the formula (III), X denotes hydrogen or a radical that can be removed by hydrolysis or alcoholysis.
公开/授权文献
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