发明授权
- 专利标题: Antibiotics from myxococcus
- 专利标题(中): 来自粘液球菌的抗生素
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申请号: US85438申请日: 1987-08-13
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公开(公告)号: US5023184A公开(公告)日: 1991-06-11
- 发明人: Hans Reichenbach , Klaus Gerth , Herbert Irschik , Brigitte Kunze , Gerhard Hofle , Hermann Augustiniak , Norbert Bedorf , Rolf Jansen , Wolfram Trowitzsch-Kienast , Heinrich Steinmetz
- 申请人: Hans Reichenbach , Klaus Gerth , Herbert Irschik , Brigitte Kunze , Gerhard Hofle , Hermann Augustiniak , Norbert Bedorf , Rolf Jansen , Wolfram Trowitzsch-Kienast , Heinrich Steinmetz
- 申请人地址: NY Ardsley DEX Braunschweig
- 专利权人: Ciba-Geigy Corporation,Gesellschaft fur Biotechnologische Forschung mbH
- 当前专利权人: Ciba-Geigy Corporation,Gesellschaft fur Biotechnologische Forschung mbH
- 当前专利权人地址: NY Ardsley DEX Braunschweig
- 优先权: CHX3294/86 19860815
- 主分类号: A61K31/495
- IPC分类号: A61K31/495 ; A61P31/04 ; A61P35/00 ; C07D471/18 ; C12P17/18 ; C12R1/01
摘要:
The invention relates to novel polycyclic alkaloids of formula ##STR1## in which R.sup.1 represents hydrogen or hydroxy, R.sup.2 represents hydrogen or acyl and A and B, independently of one another, each represents C.dbd.O or C--OH, and wherein the dashed line represents a C.dbd.C double bond at the position of the middle bond when A or B represents C.dbd.O, or at the position of the two outer bonds when A or B represents C--OH, a process for the manufacture of these compounds by fermentation of a novel microorganism of the species Myxococcus xanthus, the novel microorganism itself, pharmacetical preparations that contain the novel compounds, and the use of the novel compounds as antibiotics and as tumour-inhibiting agents and for the manufacture of pharmaceutical preparations.
公开/授权文献
- USD425898S Pick up 公开/授权日:2000-05-30