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公开(公告)号：US07759375B2
公开(公告)日：2010-07-20
申请号：US12434078
申请日：2009-05-01
IPC分类号： A61K31/427 , C07D277/24
CPC分类号： C07D417/06 , A01N43/78 , A01N43/90 , A01N63/02 , C07D493/04 , C12P17/167 , C12P17/181
摘要： The present invention relates to epothilones C, D, E, and F, their preparation and their use for the production of therapeutic compositions and compositions for plant protection.
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公开(公告)号：US07235669B2
公开(公告)日：2007-06-26
申请号：US11354769
申请日：2006-02-15
申请人： Gerhard Hoefle , Hans Reichenbach , Klaus Gerth , Ingo Hardt , Florenz Sasse , Heinrich Steinmetz
发明人： Gerhard Hoefle , Hans Reichenbach , Klaus Gerth , Ingo Hardt , Florenz Sasse , Heinrich Steinmetz
IPC分类号： C07D417/06
CPC分类号： C07D413/06 , C07D277/24 , C07D417/06 , C07D493/04
摘要： The invention concerns compounds which can be obtained by fermenting DSM 6773, especially epothilones A1, A2, A8, A9, B10, C1, C2, C3, C4, C5, C6, C7, C8, C9, D1, D2, D5, G1, G2, H1, H2, I1, I2, I3, I4, I5, I6 and K and trans-epothilones C1 and C2.
摘要翻译： 本发明涉及通过发酵DSM 6773，特别是埃坡霉素A1，A2，A8，A9，B10，C1，C2，C3，C4，C5，C6，C7，C8，C9，D1，D2，D5，G1 ，G2，H1，H2，I1，I2，I3，I4，I5，I6和K以及反式埃坡霉素C1和C2。
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公开(公告)号：US5604249A
公开(公告)日：1997-02-18
申请号：US487382
申请日：1995-06-07
申请人： Gerhard H ofle , Norbert Bedorf , Edgar Forche , Klaus Gerth , Herbert Irschik , Rolf Jansen , Brigitte Kunze , Hans Reichenbach , Florenz Sasse , Heinrich Steinmetz , Wolfram Trowitzsch-Kienast , Johannes P. Pachlatko
发明人： Gerhard H ofle , Norbert Bedorf , Edgar Forche , Klaus Gerth , Herbert Irschik , Rolf Jansen , Brigitte Kunze , Hans Reichenbach , Florenz Sasse , Heinrich Steinmetz , Wolfram Trowitzsch-Kienast , Johannes P. Pachlatko
IPC分类号： A01N43/78 , A01N63/02 , C07D417/14 , G07D417/14
CPC分类号： A01N43/78 , A01N63/02 , C07D417/14
摘要： The invention relates to compounds of the following general formula I ##STR1## especially the compound of formula Ia referred to as thiangazole ##STR2## their pharmaceutically acceptable acid addition salts, processes for their preparation and therapeutic compositions and compositions that can be used in crop-protection.
摘要翻译： 本发明涉及以下通式I的化合物，其特别是称为噻唑的式Ia化合物（Ia）其药学上可接受的酸加成盐，其制备方法 以及可用于作物保护的治疗组合物和组合物。
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公开(公告)号：US4987072A
公开(公告)日：1991-01-22
申请号：US907446
申请日：1986-09-11
申请人： Hans Reichenbach , Gerhard Hofle , Hermann Augustiniak , Norbert Bedorf , Klaus Gerth , Herbert Irschik , Rolf Jansen , Brigitte Kunze , Dietmar Schomburg , Heinrich Steinmetz , Wolfram Trowitzsch-Kienast , Victor Wray
发明人： Hans Reichenbach , Gerhard Hofle , Hermann Augustiniak , Norbert Bedorf , Klaus Gerth , Herbert Irschik , Rolf Jansen , Brigitte Kunze , Dietmar Schomburg , Heinrich Steinmetz , Wolfram Trowitzsch-Kienast , Victor Wray
IPC分类号： C07D323/00 , A61K31/357 , A61K31/365 , A61P31/04 , A61P31/12 , C07D493/22 , C07H17/08 , C12P17/18 , C12P19/62 , C12R1/01
CPC分类号： C07D493/22 , C07H17/08 , C12P19/623
摘要： The invention relates to cyclic antibiotics of formula ##STR1## wherein the prefix R represents that the substituents on the adjacent carbon atom are in the R configuration; the prefix S represents that the substituents on the adjacent carbon atom are in the S configuration; R.sub.1 is hydrogen or hydroxy and R.sub.2 is hydroxy or .beta.-glucopyranosyloxy, and to the hydrates and salts thereof, especially pharmaceutically acceptable salts.The compounds of formula I are prepared by fermentation using the strain So ce 12 (NCIB 12134) of the species Sorangium celulosum and are effective antiobiotics.
摘要翻译： 本发明涉及式（I）的环状抗生素，其中前缀R表示相邻碳原子上的取代基为R构型; 前缀S表示相邻碳原子上的取代基为S构型; R1是氢或羟基，R2是羟基或β-吡喃葡萄糖基氧基，以及其水合物和盐，特别是药学上可接受的盐。 式Ⅰ化合物是通过使用种类Sorangium celulosum的菌株So ce 12（NCIB 12134）进行发酵而制备的，并且是有效的抗生素。
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公开(公告)号：US20110136185A1
公开(公告)日：2011-06-09
申请号：US12961447
申请日：2010-12-06
IPC分类号： C12P17/16 , C07D277/30
CPC分类号： C07D417/06 , A01N43/78 , A01N43/90 , A01N63/02 , C07D493/04 , C12P17/167 , C12P17/181
摘要： The present invention relates to epothilones C, D, E, and F, their preparation and their use for the production of therapeutic compositions and compositions for plant protection.
摘要翻译： 本发明涉及埃坡霉素C，D，E和F，其制备及其用于生产用于植物保护的治疗组合物和组合物的用途。
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公开(公告)号：US20090270466A1
公开(公告)日：2009-10-29
申请号：US12434078
申请日：2009-05-01
IPC分类号： A61K31/427 , C07D415/00
CPC分类号： C07D417/06 , A01N43/78 , A01N43/90 , A01N63/02 , C07D493/04 , C12P17/167 , C12P17/181
摘要： The present invention relates to epothilones C, D, E, and F, their preparation and their use for the production of therapeutic compositions and compositions for plant protection.
摘要翻译： 本发明涉及埃坡霉素C，D，E和F，其制备及其用于生产用于植物保护的治疗组合物和组合物的用途。
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公开(公告)号：US5096922A
公开(公告)日：1992-03-17
申请号：US512963
申请日：1990-04-23
申请人： Hans Reichenbach , Gerhard Hofle , Hermann Augustiniak , Norbert Bedorf , Klaus Gerth , Herbert Irschik , Rolf Jansen , Brigitte Kunze , Dietmar Schomburg , Heinrich Steinmetz , Wolfram Trowitzsch-Kienast , Victor Wray
发明人： Hans Reichenbach , Gerhard Hofle , Hermann Augustiniak , Norbert Bedorf , Klaus Gerth , Herbert Irschik , Rolf Jansen , Brigitte Kunze , Dietmar Schomburg , Heinrich Steinmetz , Wolfram Trowitzsch-Kienast , Victor Wray
IPC分类号： C07D323/00 , A61K31/357 , A61K31/365 , A61P31/04 , A61P31/12 , C07D493/22 , C07H17/08 , C12P17/18 , C12P19/62 , C12R1/01
CPC分类号： C07D493/22 , C07H17/08 , C12P19/623
摘要： The invention relates to cyclic antibiotics of formula ##STR1## wherein the prefix R represents that the substituents on the adjacent carbon atom are in the R configuration; the prefix S represents that the substituents on the adjacent carbon atom are in the S configuration;R.sub.1 is hydrogen or hydroxy and R.sub.2 is hydroxy and salts thereof, especially pharmaceutically acceptable salts.The compounds of formula I are prepared by fermentation using the strain So ce 12 (NCIB 12134) of the species Sorangium cellulosum and are effective antibiotics.
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8.发明授权Glass elements with a conductive coating, the use thereof, as well as devices, installations and pipe conducts produced therefrom 失效具有导电涂层的玻璃元件，其使用，以及由其制造的装置，装置和管道导管公开(公告)号：US06905141B2
公开(公告)日：2005-06-14
申请号：US10276769
申请日：2001-05-14
申请人： Karl-Heinz Winter , Klaus Gerth
发明人： Karl-Heinz Winter , Klaus Gerth
CPC分类号： C03C17/005 , C03C17/32 , C03C17/328 , C03C17/3405 , F16L9/105 , F16L25/01 , F16L49/04 , Y10S285/923 , Y10T428/131
摘要： Glass modules for use in the assembly of equipment, installations and for pipe works, the surfaces of which are entirely or partially coated with a conductive coating, in particular from transparent conductive polymers for the purpose of reducing surface resistance, their use, as well as the equipment, installation and pipe works made therefrom.
摘要翻译： 用于组装设备，装置和管道工程的玻璃模块，其表面完全或部分地涂覆有导电涂层，特别是从透明导电聚合物涂覆以降低表面电阻，其用途以及 设备，安装和管道工程。
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公开(公告)号：US08076490B2
公开(公告)日：2011-12-13
申请号：US12961447
申请日：2010-12-06
IPC分类号： C07D277/22
CPC分类号： C07D417/06 , A01N43/78 , A01N43/90 , A01N63/02 , C07D493/04 , C12P17/167 , C12P17/181
摘要： The present invention relates to epothilones C, D, E, and F, their preparation and their use for the production of therapeutic compositions and compositions for plant protection.
摘要翻译： 本发明涉及埃坡霉素C，D，E和F，其制备及其用于生产用于植物保护的治疗组合物和组合物的用途。
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10.发明申请Elansolids, Novel Natural Metabolites of Flexibacter and Antibiotically Active Derivatives Thereof 审中-公开Elansolids，新颖的Flexibacter和抗生素活性衍生物的天然代谢物公开(公告)号：US20110034528A1
公开(公告)日：2011-02-10
申请号：US12918197
申请日：2009-02-19
申请人： Klaus Gerth , Heinrich Steinmetz , Gerhard Höfle
发明人： Klaus Gerth , Heinrich Steinmetz , Gerhard Höfle
IPC分类号： A61K31/4184 , C07D313/00 , C07C59/54 , C07C59/72 , C07C229/60 , C07C229/56 , C07D333/24 , C07D307/54 , C07C309/61 , C07D235/30 , A61K31/335 , A61K31/192 , A61K31/196 , A61K31/381 , A61K31/34 , A61P31/04 , C12P17/00 , C12P17/08 , C12P17/04 , C12P13/00 , C12P11/00 , C12P7/42 , C12N1/20
CPC分类号： C07C59/72 , C07C59/54 , C07C229/56 , C07C2602/08 , C07D313/00 , C12P7/42 , C12P13/001 , C12P17/08
摘要： The present invention describes Elansolids, a new class of novel anti-bacterial compounds of formula (I).
摘要翻译： 本发明描述了Elansolids，一类新的式（I）的新型抗菌化合物。
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