公开(公告)号：US5096922A

公开(公告)日：1992-03-17

申请号：US512963

申请日：1990-04-23

申请人： Hans Reichenbach ,  Gerhard Hofle ,  Hermann Augustiniak ,  Norbert Bedorf ,  Klaus Gerth ,  Herbert Irschik ,  Rolf Jansen ,  Brigitte Kunze ,  Dietmar Schomburg ,  Heinrich Steinmetz ,  Wolfram Trowitzsch-Kienast ,  Victor Wray

发明人： Hans Reichenbach ,  Gerhard Hofle ,  Hermann Augustiniak ,  Norbert Bedorf ,  Klaus Gerth ,  Herbert Irschik ,  Rolf Jansen ,  Brigitte Kunze ,  Dietmar Schomburg ,  Heinrich Steinmetz ,  Wolfram Trowitzsch-Kienast ,  Victor Wray

IPC分类号： C07D323/00 ,  A61K31/357 ,  A61K31/365 ,  A61P31/04 ,  A61P31/12 ,  C07D493/22 ,  C07H17/08 ,  C12P17/18 ,  C12P19/62 ,  C12R1/01

CPC分类号： C07D493/22 ,  C07H17/08 ,  C12P19/623

摘要： The invention relates to cyclic antibiotics of formula ##STR1## wherein the prefix R represents that the substituents on the adjacent carbon atom are in the R configuration; the prefix S represents that the substituents on the adjacent carbon atom are in the S configuration;R.sub.1 is hydrogen or hydroxy and R.sub.2 is hydroxy and salts thereof, especially pharmaceutically acceptable salts.The compounds of formula I are prepared by fermentation using the strain So ce 12 (NCIB 12134) of the species Sorangium cellulosum and are effective antibiotics.

公开(公告)号：US4987072A

公开(公告)日：1991-01-22

申请号：US907446

申请日：1986-09-11

申请人： Hans Reichenbach ,  Gerhard Hofle ,  Hermann Augustiniak ,  Norbert Bedorf ,  Klaus Gerth ,  Herbert Irschik ,  Rolf Jansen ,  Brigitte Kunze ,  Dietmar Schomburg ,  Heinrich Steinmetz ,  Wolfram Trowitzsch-Kienast ,  Victor Wray

发明人： Hans Reichenbach ,  Gerhard Hofle ,  Hermann Augustiniak ,  Norbert Bedorf ,  Klaus Gerth ,  Herbert Irschik ,  Rolf Jansen ,  Brigitte Kunze ,  Dietmar Schomburg ,  Heinrich Steinmetz ,  Wolfram Trowitzsch-Kienast ,  Victor Wray

IPC分类号： C07D323/00 ,  A61K31/357 ,  A61K31/365 ,  A61P31/04 ,  A61P31/12 ,  C07D493/22 ,  C07H17/08 ,  C12P17/18 ,  C12P19/62 ,  C12R1/01

CPC分类号： C07D493/22 ,  C07H17/08 ,  C12P19/623

摘要： The invention relates to cyclic antibiotics of formula ##STR1## wherein the prefix R represents that the substituents on the adjacent carbon atom are in the R configuration; the prefix S represents that the substituents on the adjacent carbon atom are in the S configuration; R.sub.1 is hydrogen or hydroxy and R.sub.2 is hydroxy or .beta.-glucopyranosyloxy, and to the hydrates and salts thereof, especially pharmaceutically acceptable salts.The compounds of formula I are prepared by fermentation using the strain So ce 12 (NCIB 12134) of the species Sorangium celulosum and are effective antiobiotics.

摘要翻译： 本发明涉及式（I）的环状抗生素，其中前缀R表示相邻碳原子上的取代基为R构型; 前缀S表示相邻碳原子上的取代基为S构型; R1是氢或羟基，R2是羟基或β-吡喃葡萄糖基氧基，以及其水合物和盐，特别是药学上可接受的盐。 式Ⅰ化合物是通过使用种类Sorangium celulosum的菌株So ce 12（NCIB 12134）进行发酵而制备的，并且是有效的抗生素。

公开(公告)号：US5023184A

公开(公告)日：1991-06-11

申请号：US85438

申请日：1987-08-13

申请人： Hans Reichenbach ,  Klaus Gerth ,  Herbert Irschik ,  Brigitte Kunze ,  Gerhard Hofle ,  Hermann Augustiniak ,  Norbert Bedorf ,  Rolf Jansen ,  Wolfram Trowitzsch-Kienast ,  Heinrich Steinmetz

发明人： Hans Reichenbach ,  Klaus Gerth ,  Herbert Irschik ,  Brigitte Kunze ,  Gerhard Hofle ,  Hermann Augustiniak ,  Norbert Bedorf ,  Rolf Jansen ,  Wolfram Trowitzsch-Kienast ,  Heinrich Steinmetz

IPC分类号： A61K31/495 ,  A61P31/04 ,  A61P35/00 ,  C07D471/18 ,  C12P17/18 ,  C12R1/01

CPC分类号： C07D471/18 ,  C12P17/182 ,  C12R1/01

摘要： The invention relates to novel polycyclic alkaloids of formula ##STR1## in which R.sup.1 represents hydrogen or hydroxy, R.sup.2 represents hydrogen or acyl and A and B, independently of one another, each represents C.dbd.O or C--OH, and wherein the dashed line represents a C.dbd.C double bond at the position of the middle bond when A or B represents C.dbd.O, or at the position of the two outer bonds when A or B represents C--OH, a process for the manufacture of these compounds by fermentation of a novel microorganism of the species Myxococcus xanthus, the novel microorganism itself, pharmacetical preparations that contain the novel compounds, and the use of the novel compounds as antibiotics and as tumour-inhibiting agents and for the manufacture of pharmaceutical preparations.

摘要翻译： 本发明涉及式（I）的新型多环生物碱，其中R 1表示氢或羟基，R 2表示氢或酰基，A和B彼此独立地表示C = O或C-OH，并且其中 当A或B表示C = O时，虚线表示中间键的位置处的C = C双键，或者当A或B表示C-OH时，在两个外键的位置处，制造 这些化合物通过发酵黄连球菌的新型微生物，新型微生物本身，含有新化合物的药物制剂，以及使用新化合物作为抗生素和作为肿瘤抑制剂和用于制备药物制剂。

公开(公告)号：US5610038A

公开(公告)日：1997-03-11

申请号：US487385

申请日：1995-06-07

申请人： Gerhard Hofle ,  Norbert Bedorf ,  Edgar Forche ,  Klaus Gerth ,  Herbert Irschik ,  Rolf Jansen ,  Brigitte Kunze ,  Hans Reichenbach ,  Florenz Sasse ,  Heinrich Steinmetz ,  Wolfram Trowitzsch-Kienast ,  Johannes P. Pachlatko

发明人： Gerhard Hofle ,  Norbert Bedorf ,  Edgar Forche ,  Klaus Gerth ,  Herbert Irschik ,  Rolf Jansen ,  Brigitte Kunze ,  Hans Reichenbach ,  Florenz Sasse ,  Heinrich Steinmetz ,  Wolfram Trowitzsch-Kienast ,  Johannes P. Pachlatko

IPC分类号： A01N43/78 ,  A01N63/02 ,  C07D417/14 ,  C12P17/16

CPC分类号： A01N43/78 ,  A01N63/02 ,  C07D417/14

摘要： The invention relates to compounds of the following general formula I ##STR1## especially the compound of formula Ia referred to as thiangazole ##STR2## their pharmaceutically acceptable acid addition salts, processes for their preparation and therapeutic compositions and compositions that can be used in crop-protection.

公开(公告)号：US5622979A

公开(公告)日：1997-04-22

申请号：US487384

申请日：1995-06-07

申请人： Gerhard H ofle ,  Norbert Bedorf ,  Edgar Forche ,  Klaus Gerth ,  Herbert Irschik ,  Rolf Jansen ,  Brigitte Kunze ,  Hans Reichenbach ,  Florenz Sasse ,  Heinrich Steinmetz ,  Wolfram Trowitzsch-Kienast ,  Johannes P. Pachlatko

发明人： Gerhard H ofle ,  Norbert Bedorf ,  Edgar Forche ,  Klaus Gerth ,  Herbert Irschik ,  Rolf Jansen ,  Brigitte Kunze ,  Hans Reichenbach ,  Florenz Sasse ,  Heinrich Steinmetz ,  Wolfram Trowitzsch-Kienast ,  Johannes P. Pachlatko

IPC分类号： A01N43/78 ,  A01N63/02 ,  C07D417/14

CPC分类号： A01N43/78 ,  A01N63/02 ,  C07D417/14

摘要： The invention relates to compounds of the following general formula I ##STR1## especially the compound of formula Ia referred to as thiangazole ##STR2## their pharmaceutically acceptable acid addition salts, processes for their preparation and therapeutic compositions and compositions that can be used in crop-protection.

公开(公告)号：US5604249A

公开(公告)日：1997-02-18

申请号：US487382

申请日：1995-06-07

申请人： Gerhard H ofle ,  Norbert Bedorf ,  Edgar Forche ,  Klaus Gerth ,  Herbert Irschik ,  Rolf Jansen ,  Brigitte Kunze ,  Hans Reichenbach ,  Florenz Sasse ,  Heinrich Steinmetz ,  Wolfram Trowitzsch-Kienast ,  Johannes P. Pachlatko

发明人： Gerhard H ofle ,  Norbert Bedorf ,  Edgar Forche ,  Klaus Gerth ,  Herbert Irschik ,  Rolf Jansen ,  Brigitte Kunze ,  Hans Reichenbach ,  Florenz Sasse ,  Heinrich Steinmetz ,  Wolfram Trowitzsch-Kienast ,  Johannes P. Pachlatko

IPC分类号： A01N43/78 ,  A01N63/02 ,  C07D417/14 ,  G07D417/14

CPC分类号： A01N43/78 ,  A01N63/02 ,  C07D417/14

摘要： The invention relates to compounds of the following general formula I ##STR1## especially the compound of formula Ia referred to as thiangazole ##STR2## their pharmaceutically acceptable acid addition salts, processes for their preparation and therapeutic compositions and compositions that can be used in crop-protection.

摘要翻译： 本发明涉及以下通式I的化合物，其特别是称为噻唑的式Ia化合物（Ia）其药学上可接受的酸加成盐，其制备方法 以及可用于作物保护的治疗组合物和组合物。

公开(公告)号：US08114864B2

公开(公告)日：2012-02-14

申请号：US12515695

申请日：2007-11-09

申请人： Rolf Jansen ,  Brigitte Kunze ,  Herbert Irschik

发明人： Rolf Jansen ,  Brigitte Kunze ,  Herbert Irschik

IPC分类号： A61K31/395 ,  C07D487/04

CPC分类号： A61K31/429 ,  C07D513/08

摘要： The invention provides novel Thuggacin-Type macrolide compounds which form rearrangement products forming a lacton bond to different carbon atoms. The novel compounds can be produced by fermentation of Sorangium cellulosum and Chondromyces crocatus and can be isolated by adsorption and chromoatograhic processing steps. The compounds are found to have antibiotic activity. The invention also relates to Thuggacin A, Thuggacin B, Thuggacin C, 13-Methyl-Thuggacin A, Thuggacin CMC-A, Thuggacin CMC-B and Thuggacin CMC-C AS Antimycobacterial Agents.

摘要翻译： 本发明提供了形成与不同碳原子形成内酯键的重排产物的新型Thuggacin型大环内酯化合物。 新型化合物可以通过发酵纤维素和软骨软体来生产，可以通过吸附和色谱处理步骤进行分离。 发现这些化合物具有抗生素活性。 本发明还涉及Thuggacin A，Thuggacin B，Thuggacin C，13-甲基 - Thuggacin A，Thuggacin CMC-A，Thuggacin CMC-B和Thuggacin CMC-C AS抗分枝杆菌。

公开(公告)号：US20100113757A1

公开(公告)日：2010-05-06

申请号：US12515695

申请日：2007-11-09

申请人： Rolf Jansen ,  Brigitte Kunze ,  Herbert Irschik

发明人： Rolf Jansen ,  Brigitte Kunze ,  Herbert Irschik

IPC分类号： C07H17/08

CPC分类号： A61K31/429 ,  C07D513/08

摘要： The invention provides novel Thuggacin-Type macrolide compounds which form rearrangement products forming a lacton bond to different carbon atoms. The novel compounds can be produced by fermentation of Sorangium cellulosum and Chondromyces crocatus and can be isolated by adsorption and chromoatograhic processing steps. The compounds are found to have antibiotic activity. The invention also relates to Thuggacin A, Thuggacin B, Thuggacin C, 13-Methyl-Thuggacin A, Thuggacin CMC-A, Thuggacin CMC-B and Thuggacin CMC-C AS Antimycobacterial Agents.

摘要翻译： 本发明提供了形成与不同碳原子形成内酯键的重排产物的新型Thuggacin型大环内酯化合物。 新型化合物可以通过发酵纤维素和软骨软体来生产，可以通过吸附和色谱处理步骤进行分离。 发现这些化合物具有抗生素活性。 本发明还涉及Thuggacin A，Thuggacin B，Thuggacin C，13-甲基 - Thuggacin A，Thuggacin CMC-A，Thuggacin CMC-B和Thuggacin CMC-C AS抗分枝杆菌。

公开(公告)号：US20090311264A1

公开(公告)日：2009-12-17

申请号：US12263981

申请日：2009-04-07

申请人： Herbert Irschik ,  Rolf Jansen ,  Florenz Sasse ,  Silke Baasner ,  Peter Schmidt ,  Eckhard Gunther

发明人： Herbert Irschik ,  Rolf Jansen ,  Florenz Sasse ,  Silke Baasner ,  Peter Schmidt ,  Eckhard Gunther

IPC分类号： A61K31/424 ,  A61P35/00 ,  A61K31/437 ,  A61K31/704 ,  A61K31/675 ,  A61K31/519 ,  A61K39/395 ,  A61K31/506 ,  A61K31/5377

CPC分类号： C07D498/18 ,  A61K31/424 ,  C07D498/22 ,  Y02A50/411

摘要： The invention relates to disorazoles of the general formula I, which are employed as medicaments, preferably for the treatment of oncoses, in particular in the case of pharmaceutical resistance to other active compounds and in the case of metastasizing carcinoma. The possible uses are not restricted to oncoses.

摘要翻译： 本发明涉及通式I的二异恶唑，其用作药物，优选用于治疗肿瘤，特别是在药物对其它活性化合物的耐药性和转移癌的情况下。 可能的用途并不仅限于止血剂。

公开(公告)号：US20070021480A1

公开(公告)日：2007-01-25

申请号：US11486140

申请日：2006-07-13

申请人： Herbert Irschik ,  Rolf Jansen ,  Florenz Sasse

发明人： Herbert Irschik ,  Rolf Jansen ,  Florenz Sasse

IPC分类号： A61K31/424 ,  C07D491/14

CPC分类号： C07D498/18 ,  C07D498/22

摘要： The present invention relates to a novel group of compounds having antibiotic, antifungal and/or cytostatic properties, which are obtainable from myxobacteria, especially of the genus Sorangium, preferably Sorangium cellulosum. One representative of this group of compoundsis currently named Disorazole Z and Disorazole Z-epoxide, respectively, with specific substituents and specific unsaturated bonds to its cyclic core structure:

摘要翻译： 本发明涉及一种具有抗生素，抗真菌和/或细胞生长抑制性质的新型化合物，其可从粘液细菌，特别是Sorangium属，优选Sorangium cellulosum获得。 这组化合物的一个代表目前分别名为Disorazole Z和Disorazole Z-环氧化物，具有特定的取代基和特定的不饱和键与其环状核心结构：