公开(公告)号：US5023184A

公开(公告)日：1991-06-11

申请号：US85438

申请日：1987-08-13

申请人： Hans Reichenbach ,  Klaus Gerth ,  Herbert Irschik ,  Brigitte Kunze ,  Gerhard Hofle ,  Hermann Augustiniak ,  Norbert Bedorf ,  Rolf Jansen ,  Wolfram Trowitzsch-Kienast ,  Heinrich Steinmetz

发明人： Hans Reichenbach ,  Klaus Gerth ,  Herbert Irschik ,  Brigitte Kunze ,  Gerhard Hofle ,  Hermann Augustiniak ,  Norbert Bedorf ,  Rolf Jansen ,  Wolfram Trowitzsch-Kienast ,  Heinrich Steinmetz

IPC分类号： A61K31/495 ,  A61P31/04 ,  A61P35/00 ,  C07D471/18 ,  C12P17/18 ,  C12R1/01

CPC分类号： C07D471/18 ,  C12P17/182 ,  C12R1/01

摘要： The invention relates to novel polycyclic alkaloids of formula ##STR1## in which R.sup.1 represents hydrogen or hydroxy, R.sup.2 represents hydrogen or acyl and A and B, independently of one another, each represents C.dbd.O or C--OH, and wherein the dashed line represents a C.dbd.C double bond at the position of the middle bond when A or B represents C.dbd.O, or at the position of the two outer bonds when A or B represents C--OH, a process for the manufacture of these compounds by fermentation of a novel microorganism of the species Myxococcus xanthus, the novel microorganism itself, pharmacetical preparations that contain the novel compounds, and the use of the novel compounds as antibiotics and as tumour-inhibiting agents and for the manufacture of pharmaceutical preparations.

摘要翻译： 本发明涉及式（I）的新型多环生物碱，其中R 1表示氢或羟基，R 2表示氢或酰基，A和B彼此独立地表示C = O或C-OH，并且其中 当A或B表示C = O时，虚线表示中间键的位置处的C = C双键，或者当A或B表示C-OH时，在两个外键的位置处，制造 这些化合物通过发酵黄连球菌的新型微生物，新型微生物本身，含有新化合物的药物制剂，以及使用新化合物作为抗生素和作为肿瘤抑制剂和用于制备药物制剂。

公开(公告)号：US5096922A

公开(公告)日：1992-03-17

申请号：US512963

申请日：1990-04-23

申请人： Hans Reichenbach ,  Gerhard Hofle ,  Hermann Augustiniak ,  Norbert Bedorf ,  Klaus Gerth ,  Herbert Irschik ,  Rolf Jansen ,  Brigitte Kunze ,  Dietmar Schomburg ,  Heinrich Steinmetz ,  Wolfram Trowitzsch-Kienast ,  Victor Wray

发明人： Hans Reichenbach ,  Gerhard Hofle ,  Hermann Augustiniak ,  Norbert Bedorf ,  Klaus Gerth ,  Herbert Irschik ,  Rolf Jansen ,  Brigitte Kunze ,  Dietmar Schomburg ,  Heinrich Steinmetz ,  Wolfram Trowitzsch-Kienast ,  Victor Wray

IPC分类号： C07D323/00 ,  A61K31/357 ,  A61K31/365 ,  A61P31/04 ,  A61P31/12 ,  C07D493/22 ,  C07H17/08 ,  C12P17/18 ,  C12P19/62 ,  C12R1/01

CPC分类号： C07D493/22 ,  C07H17/08 ,  C12P19/623

摘要： The invention relates to cyclic antibiotics of formula ##STR1## wherein the prefix R represents that the substituents on the adjacent carbon atom are in the R configuration; the prefix S represents that the substituents on the adjacent carbon atom are in the S configuration;R.sub.1 is hydrogen or hydroxy and R.sub.2 is hydroxy and salts thereof, especially pharmaceutically acceptable salts.The compounds of formula I are prepared by fermentation using the strain So ce 12 (NCIB 12134) of the species Sorangium cellulosum and are effective antibiotics.

公开(公告)号：US4987072A

公开(公告)日：1991-01-22

申请号：US907446

申请日：1986-09-11

申请人： Hans Reichenbach ,  Gerhard Hofle ,  Hermann Augustiniak ,  Norbert Bedorf ,  Klaus Gerth ,  Herbert Irschik ,  Rolf Jansen ,  Brigitte Kunze ,  Dietmar Schomburg ,  Heinrich Steinmetz ,  Wolfram Trowitzsch-Kienast ,  Victor Wray

发明人： Hans Reichenbach ,  Gerhard Hofle ,  Hermann Augustiniak ,  Norbert Bedorf ,  Klaus Gerth ,  Herbert Irschik ,  Rolf Jansen ,  Brigitte Kunze ,  Dietmar Schomburg ,  Heinrich Steinmetz ,  Wolfram Trowitzsch-Kienast ,  Victor Wray

IPC分类号： C07D323/00 ,  A61K31/357 ,  A61K31/365 ,  A61P31/04 ,  A61P31/12 ,  C07D493/22 ,  C07H17/08 ,  C12P17/18 ,  C12P19/62 ,  C12R1/01

CPC分类号： C07D493/22 ,  C07H17/08 ,  C12P19/623

摘要： The invention relates to cyclic antibiotics of formula ##STR1## wherein the prefix R represents that the substituents on the adjacent carbon atom are in the R configuration; the prefix S represents that the substituents on the adjacent carbon atom are in the S configuration; R.sub.1 is hydrogen or hydroxy and R.sub.2 is hydroxy or .beta.-glucopyranosyloxy, and to the hydrates and salts thereof, especially pharmaceutically acceptable salts.The compounds of formula I are prepared by fermentation using the strain So ce 12 (NCIB 12134) of the species Sorangium celulosum and are effective antiobiotics.

摘要翻译： 本发明涉及式（I）的环状抗生素，其中前缀R表示相邻碳原子上的取代基为R构型; 前缀S表示相邻碳原子上的取代基为S构型; R1是氢或羟基，R2是羟基或β-吡喃葡萄糖基氧基，以及其水合物和盐，特别是药学上可接受的盐。 式Ⅰ化合物是通过使用种类Sorangium celulosum的菌株So ce 12（NCIB 12134）进行发酵而制备的，并且是有效的抗生素。